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104 Result(s)
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Article
Diagnosis, treatment and prevention of severe acute respiratory syndrome coronavirus 2 infection in children: experts’ consensus statement updated for the Omicron variant
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Article
Open AccessITGAM-mediated macrophages contribute to basement membrane damage in diabetic nephropathy and atherosclerosis
Diabetic nephropathy (DN) and atherosclerosis (AS) are prevalent and severe complications associated with diabetes, exhibiting lesions in the basement membrane, an essential component found within the glomerul...
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Acetyl-CoA synthetase 2 promotes diabetic renal tubular injury in mice by rewiring fatty acid metabolism through SIRT1/ChREBP pathway
Diabetic nephropathy (DN) is characterized by chronic low-grade renal inflammatory responses, which greatly contribute to disease progression. Abnormal glucose metabolism disrupts renal lipid metabolism, leadi...
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Open AccessA stress-induced cilium-to-PML-NB route drives senescence initiation
Cellular senescence contributes to tissue homeostasis and age-related pathologies. However, how senescence is initiated in stressed cells remains vague. Here, we discover that exposure to irradiation, oxidativ...
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Article
Diagnosis, treatment, and prevention of monkeypox in children: an experts’ consensus statement
Monkeypox is a zoonotic disease. Since the first human monkeypox case was detected in 1970, it has been prevalent in some countries in central and western Africa. Since May 2022, monkeypox cases have been repo...
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Deposition of platelet-derived microparticles in podocytes contributes to diabetic nephropathy
Diabetic nephropathy (DN) is the leading cause of end-stage renal disease in the developed world. Podocyte injury is a critical cellular event involved in the progression of DN. Our previous studies demonstrat...
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Open AccessUsing External Joint Stabilizer – Elbow (EJS-E) for treating elbow instability—biomechanical assessment and clinical outcomes
This study aimed to evaluate the outcome of using an External Joint Stabilizer – Elbow (EJS-E) for persistent elbow instability based on biomechanical experiments and analysis of clinical results.
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Enhanced thermoelectric performance of Cu2SnSe3 via synergistic effects of Cd-do** and CuGaTe2 alloying
In this work, we show significantly enhanced thermoelectric performance in Cu2SnSe3 via a synergistic effect of Cd-do** and CuGaTe2 alloying in the temperature range of 300–823 K. Both the electron and phonon t...
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Article
Asthma mortality among children and adolescents in China, 2008–2018
Asthma mortality among children and adolescents at the national level in China was unreported. The aim of this study was to analyze the mortality of asthma among children and adolescents in China using a natio...
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Article
The Er:YAG vaginal laser for management of women with genitourinary syndrome of menopause (GSM)
The purpose of our study was to investigate the effects of vulvovaginal erbium laser on the genitourinary syndrome of menopause (GSM) and sexual function of postmenopausal women. We conducted a retrospective s...
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Open AccessChanges in sexual function and vaginal topography using transperineal ultrasound after vaginal laser treatment for women with stress urinary incontinence
We aim to assess the changes in sexual function and vaginal topography using 3-D transperineal ultrasound in stress-incontinent women treated with Er:YAG vaginal laser. Two hundred and twenty women with stress...
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Article
Open AccessLow-level laser prevents doxorubicin-induced skeletal muscle atrophy by modulating AMPK/SIRT1/PCG-1α-mediated mitochondrial function, apoptosis and up-regulation of pro-inflammatory responses
Doxorubicin (Dox) is a widely used anthracycline drug to treat cancer, yet numerous adverse effects influencing different organs may offset the treatment outcome, which in turn affects the patient’s quality of...
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Article
Confining isolated chromophores for highly efficient blue phosphorescence
High-efficiency blue phosphorescence emission is essential for organic optoelectronic applications. However, synthesizing heavy-atom-free organic systems having high triplet energy levels and suppressed non-ra...
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Open AccessHybrid versus total sublaminar wires in patients with spinal muscular atrophy undergoing scoliosis surgery
Early versions of spinal muscular atrophy (SMA) scoliosis correction surgery often involved sublaminar devices. Recently, the utilization of pedicle screws has gained much popularity. Pedicle screws are genera...
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Article
Global Pediatric Pulmonology Alliance (GPPA) proposal for COVID-19 vaccination in children
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COVID-19 in children and the importance of COVID-19 vaccination
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Expert consensus on COVID-19 vaccination in children
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Open AccessTwo novel mutations in TCIRG1 induced infantile malignant osteopetrosis: a case report
Infantile malignant osteopetrosis (IMO) is a rare autosomal recessive disease characterized by a higher bone density in bone marrow caused by the dysfunction of bone resorption. Clinically, IMO can be diagnose...
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Open AccessDapagliflozin attenuates hypoxia/reoxygenation-caused cardiac dysfunction and oxidative damage through modulation of AMPK
Emerging evidence demonstrated dapagliflozin (DAPA), a sodium-glucose cotransporter 2 inhibitor, prevented various cardiovascular events. However, the detailed mechanisms underlying its cardioprotective proper...
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Open AccessA pilot study: effectiveness of local injection of autologous platelet-rich plasma in treating women with stress urinary incontinence
The study aims to evaluate the effectiveness of local injection of autologous platelet rich plasma (A-PRP) as a treatment for women suffering from stress urinary incontinence (SUI). In a prospective interventi...