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Article
Diagnosis, treatment and prevention of severe acute respiratory syndrome coronavirus 2 infection in children: experts’ consensus statement updated for the Omicron variant
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Article
Open AccessPatterns of antibiotic administration in Chinese neonates: results from a multi-center, point prevalence survey
In this study, we describe the patterns of antibiotic prescription for neonates based on World Health Organization’s (WHO) Essential Medicines List Access, Watch, and Reserve (AWaRe), and the Management of Ant...
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Article
Open AccessDevelopment and validation of a model for early diagnosis of biliary atresia
Early diagnosis of biliary atresia (BA), particularly distinguishing it from other causes of neonatal cholestasis (NC), is challenging. This study aimed to design and validate a predictive model for BA by usin...
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Article
Diagnosis, treatment, and prevention of monkeypox in children: an experts’ consensus statement
Monkeypox is a zoonotic disease. Since the first human monkeypox case was detected in 1970, it has been prevalent in some countries in central and western Africa. Since May 2022, monkeypox cases have been repo...
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Article
Open AccessImpact of extracorporeal membrane oxygenation in immunocompetent children with severe adenovirus pneumonia
Severe adenovirus (Adv.) pneumonia can cause significant mortality in young children. There has been no worldwide consensus on the impact of extracorporeal membrane oxygenation (ECMO) in immunocompetent children ...
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Open AccessRespiratory infections in X-linked hyper-IgM syndrome with CD40LG mutation: a case series of seven children in China
X-linked hyper-immunoglobulin M (XHIGM), a primary immunodeficiency syndrome caused by mutations in the CD40 ligand gene(CD40LG), presents with recurrent respiratory infections in pediatric patients. We aimed to ...
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Article
Genetic characteristics of human coronavirus HKU1 in mainland China during 2018
Human coronavirus HKU1 (HCoV-HKU1) is a pathogen that causes acute respiratory tract infections in children and circulates worldwide. To investigate the molecular characteristics and genetic diversity of HCoV-...
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Article
Open AccessTREM2/β-catenin attenuates NLRP3 inflammasome-mediated macrophage pyroptosis to promote bacterial clearance of pyogenic bacteria
Triggering receptors expressed on myeloid cells 2 (TREM2) is considered a protective factor to protect host from bacterial infection, while how it elicits this role is unclear. In the present study, we demonst...
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Article
Open AccessTalaromyces marneffei infection associated with bronchiolitis obliterans in an HIV-negative child: a case report
Talaromyces marneffei is an opportunistic pathogen that infects immunodeficient and immunocompromised patients. We presented a pediatric patient with a diagnosis of T. marneffei infection who was followed up in t...
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A multi-center study on Molecular Epidemiology of Human Respiratory Syncytial Virus from Children with Acute Lower Respiratory Tract Infections in the Mainland of China between 2015 and 2019
Human respiratory syncytial virus (RSV) is a major pathogen of acute lower respiratory tract infection among young children. To investigate the prevalence and genetic characteristics of RSV in China, we perfor...
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Open AccessInfluence of the timing of bronchoscopic alveolar lavage on children with adenovirus pneumonia: a comparative study
Adenovirus pneumonia is prone to severe clinical and imaging manifestations in children. Bronchoscopic alveolar lavage (BAL) is an important adjunctive therapy for patients with severe imaging findings. The st...
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Open AccessMortality risk factors among hospitalized children with severe pertussis
Some children hospitalized for severe pertussis need intensive care; moreover, some children die because of deterioration alone or in combination with other complications. The purpose of this study was to iden...
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Article
Global Pediatric Pulmonology Alliance (GPPA) proposal for COVID-19 vaccination in children
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Expert consensus on COVID-19 vaccination in children
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Open AccessTwo novel mutations in TCIRG1 induced infantile malignant osteopetrosis: a case report
Infantile malignant osteopetrosis (IMO) is a rare autosomal recessive disease characterized by a higher bone density in bone marrow caused by the dysfunction of bone resorption. Clinically, IMO can be diagnose...
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Article
Open AccessThe interferon-stimulated exosomal hACE2 potently inhibits SARS-CoV-2 replication through competitively blocking the virus entry
Since the outbreak of coronavirus disease 2019 (COVID-19), it has become a global pandemic. The spike (S) protein of etiologic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) specifically recogniz...
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Article
Open AccessHost-derived lipids orchestrate pulmonary γδ T cell response to provide early protection against influenza virus infection
Innate immunity is important for host defense by eliciting rapid anti-viral responses and bridging adaptive immunity. Here, we show that endogenous lipids released from virus-infected host cells activate lung ...
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Open AccessPeripheral immune profile of children with Talaromyces marneffei infections: a retrospective analysis of 21 cases
Talaromyces marneffei (T. marneffei) is an opportunistic pathogen that infects immunodeficient children. The aim of the study is to determine the clinical features and peripheral immune state of Talaromyces marne...
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Article
Global Pediatric Pulmonology Alliance recommendation to strengthen prevention of pediatric seasonal influenza under COVID-19 pandemic
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Open AccessAn insight into the transmission role of insect vectors based on the examination of gene characteristics of African swine fever virus originated from non-blood sucking flies in pig farm environments
Insect vector transmitted pathogens from contaminated environments are a key potential risk for public health. Meanwhile, transmission by non-blood sucking flies needs to be considered. Sequencing and phylogen...
