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Article
Open AccessMegakaryocytic IGF1 coordinates activation and ferroptosis to safeguard hematopoietic stem cell regeneration after radiation injury
Hematopoietic stem cell (HSC) regeneration underlies hematopoietic recovery from myelosuppression, which is a life-threatening side effect of cytotoxicity. HSC niche is profoundly disrupted after myelosuppress...
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Article
Open AccessApoptosis-resistant megakaryocytes produce large and hyperreactive platelets in response to radiation injury
The essential roles of platelets in thrombosis have been well recognized. Unexpectedly, thrombosis is prevalent during thrombocytopenia induced by cytotoxicity of biological, physical and chemical origins, whi...
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Article
Aged hematopoietic stem cells entrap regulatory T cells to create a prosurvival microenvironment
Although DNA mutation drives stem cell aging, how mutation-accumulated stem cells obtain clonal advantage during aging remains poorly understood. Here, using a mouse model of irradiation-induced premature agin...
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Article
Open AccessIntratumoral PD-1+CD8+ T cells associate poor clinical outcomes and adjuvant chemotherapeutic benefit in gastric cancer
Although PD-1 has been reported to be a marker of T-cell exhaustion in several malignancies, the biological role of PD-1+CD8+ T cells in gastric cancer (GC) remains unclear. Herein, we aimed to investigate the ro...
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Article
Lauren classification identifies distinct prognostic value and functional status of intratumoral CD8+ T cells in gastric cancer
With dichotomous etiology and pathogenesis, intestinal type and diffuse type gastric cancers vary in their clinical and molecular features to the point of representing distinct entities. However, the differenc...
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Article
Open AccessIdentification and validation of an immunogenic subtype of gastric cancer with abundant intratumoural CD103+CD8+ T cells conferring favourable prognosis
Intratumoural CD103+CD8+ T cells have been linked to prolonged survival in several malignancies. However, the clinical significance of CD103+CD8+ T cells in gastric cancer remains unexplored.
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Chapter and Conference Paper
The overall Merit of Master Production Schedule Based on Rolling Planning Cycles and Freezing Parameters
Nowadays, customer demand in manufacturing industry changes more frequent, moreover, the requirement of lead-time should be minimized. Therefore, manufacturing enterprises should make the MPS rapidly according...
