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Article
Open AccessExtracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions
Central Nervous System (CNS) disorders represent a profound public health challenge that affects millions of people around the world. Diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and tr...
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Article
Open AccessNanotechnology-enabled immunoengineering approaches to advance therapeutic applications
Immunotherapy has reached clinical success in the last decade, with the emergence of new and effective treatments such as checkpoint blockade therapy and CAR T-cell therapy that have drastically improved patie...
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Article
Open AccessGeneration of uniform-sized multicellular tumor spheroids using hydrogel microwells for advanced drug screening
Even though in vitro co-culture tumor spheroid model plays an important role in screening drug candidates, its wide applications are currently limited due to the lack of reliable and high throughput methods for g...
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Article
Open AccessA biodegradable hybrid inorganic nanoscaffold for advanced stem cell therapy
Stem cell transplantation, as a promising treatment for central nervous system (CNS) diseases, has been hampered by crucial issues such as a low cell survival rate, incomplete differentiation, and limited neur...
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Article
Open AccessMultidimensional nanomaterials for the control of stem cell fate
Current stem cell therapy suffers low efficiency in giving rise to differentiated cell lineages, which can replace the original damaged cells. Nanomaterials, on the other hand, provide unique physical size, su...
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Article
Open AccessNanotopography-mediated Reverse Uptake for siRNA Delivery into Neural Stem Cells to Enhance Neuronal Differentiation
RNA interference (RNAi) for controlling gene expression levels using siRNA or miRNA is emerging as an important tool in stem cell biology. However, the conventional methods used to deliver siRNA into stem cell...
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Article
Open AccessIncorporation of functionalized gold nanoparticles into nanofibers for enhanced attachment and differentiation of mammalian cells
Electrospun nanofibers have been widely used as substrata for mammalian cell culture owing to their structural similarity to natural extracellular matrices. Structurally consistent electrospun nanofibers can b...
