16 Result(s)

Article

Falsified and problematic methandienone products available online: active pharmaceutical ingredient identification by portable Raman spectrometers and quantification by ultra-high-performance liquid chromatography–Fourier transform mass spectrometry

This study aimed on the one hand to clarify the quality, authenticity, safety, and other issues related to products of the anabolic-androgenic steroid methandienone advertised on the Internet and personally im...

Robin Schreiber, Manami Hori, Chisato Takahashi, Mohammad Sofiqur Rahman… in AAPS Open (2024)

Article

Lipidomic signatures of aortic media from patients with atherosclerotic and nonatherosclerotic aneurysms

Aortic aneurysms are associated with fatal aortic rupture. Current therapeutic approaches are limited to implantation of aortic prostheses and stent-grafts; no effective drugs are available because the pathoge...

Kosuke Saito, Hiroaki Yagi, Keiko Maekawa, Mitsuhiro Nishigori… in Scientific Reports (2019)

Article

Lipidomic Signatures and Associated Transcriptomic Profiles of Clear Cell Renal Cell Carcinoma

Renal cell carcinoma (RCC) is the most common histological type of adult kidney cancer. In this study, we obtained lipidomic profiles of clear cell RCC (ccRCC), a major RCC subtype, by performing a lipidomic a...

Kosuke Saito, Eri Arai, Keiko Maekawa, Masaki Ishikawa… in Scientific Reports (2016)

Article

Plasma lipid profiling of different types of hepatic fibrosis induced by carbon tetrachloride and lomustine in rats

Plasma lipid profiling has emerged as a useful tool for understanding the pathophysiology of hepatic injury and disease. Hepatic fibrosis results from chronic, progressive damage to the liver and can lead, in ...

Masaki Ishikawa, Kosuke Saito, Hiroshi Yamada… in Lipids in Health and Disease (2016)

Article

Comparison of circulating lipid profiles between fasting humans and three animal species used in preclinical studies: mice, rats and rabbits

Circulating lipid metabolites are associated with many physiological and biological processes in the body, and therefore could be used as biomarkers for evaluating drug efficacy and safety in preclinical studi...

Masaki Ishikawa, Kosuke Saito, Masayo Urata, Yuji Kumagai… in Lipids in Health and Disease (2015)

Article

Characterization of hepatic lipid profiles in a mouse model with nonalcoholic steatohepatitis and subsequent fibrosis

Nonalcoholic steatohepatitis (NASH) is a major health problem since it often leads to hepatocellular carcinoma. However, the underlying mechanisms of NASH development and subsequent fibrosis have yet to be cla...

Kosuke Saito, Takashi Uebanso, Keiko Maekawa, Masaki Ishikawa… in Scientific Reports (2015)

Article

Medication tendencies for inducing severe ocular surface symptoms in Japanese Stevens-Johnson Syndrome / toxic epidermal necrolysis patients

Yoshiro Saito, Mayumi Ueta, Ryosuke Nakamura… in Clinical and Translational Allergy (2014)

Article

HLA association with antipyretic analgesics-induced Stevens-Johnson Syndrome/toxic epidermal necrolysis with severe ocular surface complications in japanese patients

Ryosuke Nakamura, Nahoko Kaniwa, Mayumi Ueta… in Clinical and Translational Allergy (2014)

Article

Independent strong association of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe mucosal involvement

Stevens-Johnson syndrome (SJS) and its severe variant, toxic epidermal necrolysis (TEN), are acute inflammatory vesiculobullous reactions of the skin and mucous membranes. Cold medicines including non-steroida...

Mayumi Ueta, Nahoko Kaniwa, Chie Sotozono, Katsushi Tokunaga… in Scientific Reports (2014)

Article

Lipidomic analysis of brain tissues and plasma in a mouse model expressing mutated human amyloid precursor protein/tau for Alzheimer’s disease

Alzheimer’s disease (AD), the most common cause of dementia among neurodegenerative diseases, afflicts millions of elderly people worldwide. In addition to amyloid-beta (Aβ) peptide and phosphorylated tau, lip...

Yoko Tajima, Masaki Ishikawa, Keiko Maekawa… in Lipids in Health and Disease (2013)

Article

Genetic Variations of CYP2C9 in 724 Japanese Individuals and Their Impact on the Antihypertensive Effects of Losartan

CYP2C9, a drug-metabolizing enzyme, converts the angiotensin II receptor blocker losartan to its active form, which is responsible for its antihypertensive effect. We resequenced CYP2C9 in 724 Japanese individ...

Tong Yin, Keiko Maekawa, Kei Kamide, Yoshiro Saito… in Hypertension Research (2008)

Article

Genetic variations and haplotype structures of the DPYD gene encoding dihydropyrimidine dehydrogenase in Japanese and their ethnic differences

Dihydropyrimidine dehydrogenase (DPD) is an inactivating and rate-limiting enzyme for 5-fluorouracil (5-FU), and its deficiency is associated with a risk for develo** a severe or fatal toxicity to 5-FU. In t...

Keiko Maekawa, Mayumi Saeki, Yoshiro Saito, Shogo Ozawa… in Journal of Human Genetics (2007)