17 Result(s)
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Article
Open AccessCombinatorial characterization of metastable luminous silver cations
Thermodynamically metastable glasses that can contain metastable species are important functional materials. X-ray absorption near-edge structure (XANES) spectroscopy is an effective technique for determining ...
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Open AccessEffects of the novel selective κ-opioid receptor agonist NP-5497-KA on morphine-induced reward-related behaviors
Opioid addiction and the opioid overdose epidemic are becoming more serious, and the development of therapeutic agents is essential for the pharmacological treatment of substance use disorders. The κ-opioid re...
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Open AccessGut microbial carbohydrate metabolism contributes to insulin resistance
Insulin resistance is the primary pathophysiology underlying metabolic syndrome and type 2 diabetes1,2. Previous metagenomic studies have described the characteristics of gut microbiota and their roles in metabol...
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Open AccessLysophosphatidylserine induces necrosis in pressure overloaded male mouse hearts via G protein coupled receptor 34
Heart failure is a leading cause of mortality in developed countries. Cell death is a key player in the development of heart failure. Calcium-independent phospholipase A2β (iPLA2β) produces lipid mediators by cat...
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Open AccessAuthor Correction: Hidden chemical order in disordered Ba7Nb4MoO20 revealed by resonant X-ray diffraction and solid-state NMR
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Article
Open AccessHidden chemical order in disordered Ba7Nb4MoO20 revealed by resonant X-ray diffraction and solid-state NMR
The chemical order and disorder of solids have a decisive influence on the material properties. There are numerous materials exhibiting chemical order/disorder of atoms with similar X-ray atomic scattering fac...
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Open AccessLong-chain saturated fatty acids in breast milk are associated with the pathogenesis of atopic dermatitis via induction of inflammatory ILC3s
Breastfeeding influences the immune system development in infants and may even affect various immunological responses later in life. Breast milk provides a rich source of early nutrition for infant growth and ...
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Open AccessStrain-induced creation and switching of anion vacancy layers in perovskite oxynitrides
Perovskite oxides can host various anion-vacancy orders, which greatly change their properties, but the order pattern is still difficult to manipulate. Separately, lattice strain between thin film oxides and a...
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Open AccessUltralow thermal conductivity from transverse acoustic phonon suppression in distorted crystalline α-MgAgSb
Low thermal conductivity is favorable for preserving the temperature gradient between the two ends of a thermoelectric material, in order to ensure continuous electron current generation. In high-performance t...
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Open AccessCharacteristic fast H− ion conduction in oxygen-substituted lanthanum hydride
Fast ionic conductors have considerable potential to enable technological development for energy storage and conversion. Hydride (H−) ions are a unique species because of their natural abundance, light mass, and ...
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Article
Open AccessAutophagy regulates lipid metabolism through selective turnover of NCoR1
Selective autophagy ensures the removal of specific soluble proteins, protein aggregates, damaged mitochondria, and invasive bacteria from cells. Defective autophagy has been directly linked to metabolic disor...
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Open AccessElastic and dynamical structural properties of La and Mn-doped SrTiO3 studied by neutron scattering and their relation with thermal conductivities
The electron-doped SrTiO3 exhibits good thermoelectric properties, which makes this material a promising candidate of an n-type oxide thermoelectric device. Recent studies indicated that only a few percent co-dop...
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Open AccessFormation of novel transition metal hydride complexes with ninefold hydrogen coordination
Ninefold coordination of hydrogen is very rare, and has been observed in two different hydride complexes comprising rhenium and technetium. Herein, based on a theoretical/experimental approach, we present evid...
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Article
Open AccessPNPLA1 has a crucial role in skin barrier function by directing acylceramide biosynthesis
Mutations in patatin-like phospholipase domain-containing 1 (PNPLA1) cause autosomal recessive congenital ichthyosis, but the mechanism involved remains unclear. Here we show that PNPLA1, an enzyme expressed i...
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Global metabolic network reorganization by adaptive mutations allows fast growth of Escherichia coli on glycerol
Comparative whole-genome sequencing enables the identification of specific mutations during adaptation of bacteria to new environments and allelic replacement can establish their causality. However, the mechan...
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Open AccessFunctional lacrimal gland regeneration by transplantation of a bioengineered organ germ
The lacrimal gland has a multifaceted role in maintaining a homeostatic microenvironment for a healthy ocular surface via tear secretion. Dry-eye disease, which is caused by lacrimal gland dysfunction, is one ...
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Open AccessRapamycin reverses impaired social interaction in mouse models of tuberous sclerosis complex
Impairment of reciprocal social interaction is a core symptom of autism spectrum disorder. Genetic disorders frequently accompany autism spectrum disorder, such as tuberous sclerosis complex caused by haploins...
