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Article
Open AccessArtificial intelligence to estimate the tear film breakup time and diagnose dry eye disease
The use of artificial intelligence (AI) in the diagnosis of dry eye disease (DED) remains limited due to the lack of standardized image formats and analysis models. To overcome these issues, we used the Smart ...
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Article
Open AccessNaringenin potentiates anti-tumor immunity against oral cancer by inducing lymph node CD169-positive macrophage activation and cytotoxic T cell infiltration
The CD169+ macrophages in lymph nodes are implicated in cytotoxic T lymphocyte (CTL) activation and are associated with improved prognosis in several malignancies. Here, we investigated the significance of CD169+
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Article
Strategies for Regenerating the Lacrimal Gland
Aqueous deficient dry eye disease, a significant cause of morbidity worldwide, is due to dysfunction of the main and accessory lacrimal glands. Recent advances in efforts to regenerate lacrimal gland are revie...
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Article
Open AccessIdentification of transcription factors that promote the differentiation of human pluripotent stem cells into lacrimal gland epithelium-like cells
Dry eye disease is the most prevalent pathological condition in aging eyes. One potential therapeutic strategy is the transplantation of lacrimal glands, generated in vitro from pluripotent stem cells such as ...
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Protocol
Generation of a Bioengineered Lacrimal Gland by Using the Organ Germ Method
In organogenesis including lacrimal gland development, cell arrangement within a tissue plays an important role. The lacrimal gland develops from embryonic ocular surface epithelium through reciprocal epitheli...
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Chapter
Functional Lacrimal Gland Regeneration
The lacrimal gland is an indispensable organ to secrete tear for maintaining a homeostatic microenvironment for healthy ocular surfaces. The lacrimal gland develops from its organ germ at ocular epithelium via...
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Article
Open AccessFunctional lacrimal gland regeneration by transplantation of a bioengineered organ germ
The lacrimal gland has a multifaceted role in maintaining a homeostatic microenvironment for a healthy ocular surface via tear secretion. Dry-eye disease, which is caused by lacrimal gland dysfunction, is one ...
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Article
Open AccessFunctional salivary gland regeneration by transplantation of a bioengineered organ germ
Salivary gland hypofunction, also known as xerostomia, occurs as a result of radiation therapy for head cancer, Sjögren’s syndrome or aging, and can cause a variety of critical oral health issues, including de...
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Article
Open AccessSurgical outcome of Descemet’s strip** automated endothelial keratoplasty for bullous keratopathy secondary to argon laser iridotomy
To report the 6-month clinical outcome of Descemet’s strip** automated endothelial keratoplasty (DSAEK) for bullous keratopathy (BK) secondary to argon laser iridotomy (ALI), and compare the results with tho...
