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Open AccessThe integration of metabolic and proteomic data uncovers an augmentation of the sphingolipid biosynthesis pathway during T-cell differentiation
Recent studies have highlighted the significance of cellular metabolism in the initiation of clonal expansion and effector differentiation of T cells. Upon exposure to antigens, naïve CD4+ T cells undergo metabol...
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Article
Open AccessStructure and particle surface analysis of Li2S–P2S5–LiI-type solid electrolytes synthesized by liquid-phase shaking
Li2S–P2S5–LiI-type solid electrolytes, such as Li4PS4I, Li7P2S8I, and Li10P3S12I, are promising candidates for anode layers in all-solid-state batteries because of their high ionic conductivity and stability towa...
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Article
Open AccessCombinatorial characterization of metastable luminous silver cations
Thermodynamically metastable glasses that can contain metastable species are important functional materials. X-ray absorption near-edge structure (XANES) spectroscopy is an effective technique for determining ...
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Article
Open AccessEffects of the novel selective κ-opioid receptor agonist NP-5497-KA on morphine-induced reward-related behaviors
Opioid addiction and the opioid overdose epidemic are becoming more serious, and the development of therapeutic agents is essential for the pharmacological treatment of substance use disorders. The κ-opioid re...
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Article
Open AccessGut microbial carbohydrate metabolism contributes to insulin resistance
Insulin resistance is the primary pathophysiology underlying metabolic syndrome and type 2 diabetes1,2. Previous metagenomic studies have described the characteristics of gut microbiota and their roles in metabol...
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Article
Open AccessLysophosphatidylserine induces necrosis in pressure overloaded male mouse hearts via G protein coupled receptor 34
Heart failure is a leading cause of mortality in developed countries. Cell death is a key player in the development of heart failure. Calcium-independent phospholipase A2β (iPLA2β) produces lipid mediators by cat...
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Open AccessAuthor Correction: Hidden chemical order in disordered Ba7Nb4MoO20 revealed by resonant X-ray diffraction and solid-state NMR
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Article
Open AccessMitochondrial genetic variants associated with bipolar disorder and Schizophrenia in a Japanese population
Bipolar disorder (BD) and schizophrenia (SZ) are complex psychotic disorders (PSY), with both environmental and genetic factors including possible maternal inheritance playing a role. Some studies have investi...
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Article
Open AccessHidden chemical order in disordered Ba7Nb4MoO20 revealed by resonant X-ray diffraction and solid-state NMR
The chemical order and disorder of solids have a decisive influence on the material properties. There are numerous materials exhibiting chemical order/disorder of atoms with similar X-ray atomic scattering fac...
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Article
Open AccessBehavioral phenotype, intestinal microbiome, and brain neuronal activity of male serotonin transporter knockout mice
The serotonin transporter (5-HTT) plays a critical role in the regulation of serotonin neurotransmission. Mice genetically deficient in 5-HTT expression have been used to study the physiological functions of 5...
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Article
Open AccessTsc2 mutation rather than Tsc1 mutation dominantly causes a social deficit in a mouse model of tuberous sclerosis complex
Tuberous sclerosis complex (TSC) is an autosomal dominant disorder that is associated with neurological symptoms, including autism spectrum disorder. Tuberous sclerosis complex is caused by pathogenic germline...
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Article
Open AccessInvolvement of muscarinic receptors in psychomotor hyperactivity in dopamine-deficient mice
Dopamine-deficient (DD) mice exhibit psychomotor hyperactivity that might be related to a decrease in muscarinic signaling. In the present study, muscarinic acetylcholine receptor M2 (CHRM2) density decreased ...
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Article
Hydride-ion-conducting K2NiF4-type Ba–Li oxyhydride solid electrolyte
Hydrogen transport in solids, applied in electrochemical devices such as fuel cells and electrolysis cells, is key to sustainable energy societies. Although using proton (H+) conductors is an attractive choice, p...
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Article
Open AccessAbolished ketamine effects on the spontaneous excitatory postsynaptic current of medial prefrontal cortex neurons in GluN2D knockout mice
Ketamine, a non-competitive antagonist of the N-methyl-d-aspartate receptor (NMDAR), generates a rapidly-acting antidepressant effect. It exerts psychomimetic effects, yet demands a further investigation of its m...
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Article
Open AccessImpaired wakefulness and rapid eye movement sleep in dopamine-deficient mice
Despite the established roles of the dopaminergic system in promoting arousal, the effects of loss of dopamine on the patterns of sleep and wakefulness remain elusive. Here, we examined the sleep architecture ...
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Article
Open AccessSCD2-mediated monounsaturated fatty acid metabolism regulates cGAS-STING-dependent type I IFN responses in CD4+ T cells
Host lipid metabolism and viral responses are intimately connected. However, the process by which the acquired immune systems adapts lipid metabolism to meet demands, and whether or not the metabolic rewiring ...
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Open AccessLong-chain saturated fatty acids in breast milk are associated with the pathogenesis of atopic dermatitis via induction of inflammatory ILC3s
Breastfeeding influences the immune system development in infants and may even affect various immunological responses later in life. Breast milk provides a rich source of early nutrition for infant growth and ...
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Open AccessCorrection to: Increase in excitability of hippocampal neurons during novelty-induced hyperlocomotion in dopamine-deficient mice
An amendment to this paper has been published and can be accessed via the original article.
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Open AccessStrain-induced creation and switching of anion vacancy layers in perovskite oxynitrides
Perovskite oxides can host various anion-vacancy orders, which greatly change their properties, but the order pattern is still difficult to manipulate. Separately, lattice strain between thin film oxides and a...
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Article
Open AccessPolygenic risk scores for late smoking initiation associated with the risk of schizophrenia
Patients with schizophrenia display characteristic smoking-related behaviors and genetic correlations between smoking behaviors and schizophrenia have been identified in European individuals. However, the gene...
