Non-Neoplastic Liver Pathology
A Pathologist’s Survival Guide
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21 Result(s)
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Chapter
Practical Gastrointestinal Oncology Correlative Science
Gastrointestinal (GI) cancers, like other human malignancies, are characterized by the accumulation of a variety of genetic alterations, including mutations that lead to inactivation of tumor suppressor genes ...
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Article
Expert pathology review and endoscopic mucosal resection alters the diagnosis of patients referred to undergo therapy for Barrett’s esophagus
Endoscopic therapy has emerged as an alternative to surgical esophagectomy for the management of Barrett’s esophagus (BE)-associated neoplasia. Accurate pretreatment staging is essential to ensure an appropria...
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Book
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Chapter
Granulomas
Granulomatous hepatitis has many forms and causes (Fig. 9.1). Varieties of granuloma in the liver include epithelioid granulomas (non-caseating or caseating), necrotic palisading granulomas (i.e., abscessed or...
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Chapter
Sinusoidal Changes
Under normal circumstances, the hepatic sinusoids are inconspicuous and therefore often ignored. They usually come to attention when dilated, as the ga** spaces between the hepatocyte plates catch the eye (F...
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Normal or Nearly Normal Liver
Not all liver specimens sent for pathologic examination will show histologic abnormalities. There are several situations that can lead to this. First, the patient may have no disease affecting the liver. This ...
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Chapter
Pigments and Inclusions
This chapter will cover a variety of mostly uncommon conditions that leave their mark by depositing material within the liver parenchyma. Some of this material is pigmented and can be quickly spotted, while ot...
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Lobular Changes
Lobular injury comes in many forms and patterns. While it is often seen as a mild “background” component of chronic liver disease (Chap. 3), it can manifest as the primary pattern of injury in more acute proce...
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Chapter
Liver Transplantation
Certain disease states only (or almost only) occur in livers transplanted into a recipient patient. They generally represent immunologic phenomena or responses to surgical injury. The most common, and most ner...
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Chapter
Cholestasis
In anatomic pathology, cholestasis refers to microscopically visible bile in a section of liver tissue (Fig. 6.1). It can be present anywhere along the biliary tree, from hepatocellular canaliculi to small or ...
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Chapter
Special and Immunohistochemical Stains
H&E alone is rarely sufficient for a non-neoplastic liver sample. At a minimum, a trichrome stain should be ordered to assess for fibrosis unless the specimen is blatantly cirrhotic. A wide variety of other sp...
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Fibrosis and Cirrhosis
This brief chapter will discuss usual and unusual patterns of fibrosis, along with approaches to cirrhosis in a patient without a known history of liver disease. Cirrhosis in the pediatric population is discus...
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Introduction
Non-neoplastic liver pathology occupies an unusual niche in surgical pathology. Several other organs (such as the skin, brain, and kidney) demonstrate complex pathophysiological changes often requiring expert ...
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Chapter
Necrosis
Small foci of cell death (such as lobular apoptotic bodies) are commonly seen in inflammatory conditions. Some diseases, however, cause more widespread, confluent necrosis, destroying a large number of cells a...
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Chapter
Portal Inflammation
Portal inflammation is probably the most commonly observed pattern of liver injury (Fig. 3.1). Two major and common disease processes – chronic viral hepatitis and autoimmune hepatitis – are characterized by p...
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Chapter
Funny-Looking Cells
This chapter serves to cover various processes typified by unusual or “funny-looking” cells. Most cause this change in hepatocytes, but macrophages and stellate cells are sometimes involved. Proliferations of ...
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Chapter
Pediatric Liver Disease
This chapter covers diseases encountered more or less exclusively in the pediatric population. Liver samples from children, especially neonates, should be approached with these conditions in mind.
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Chapter
Steatosis
Steatosis (fatty change) is a relatively common finding in liver specimens. A small amount (no more than about 5 %) is not considered pathologic, but larger amounts are often attributable to a disease state. I...
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Chapter
Biliary and Vascular Changes
The three main structures of the portal tract – hepatic artery, portal vein, and bile duct – are susceptible to injury from a variety of pathologic processes. The biliary tree is by far the most commonly damag...
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Article
Open AccessCurrent applications of molecular pathology in colorectal carcinoma
Molecular pathology is playing an increasingly important role in the treatment and overall management of patients with colorectal carcinoma. Three distinct genetic pathways have been identified that play a rol...
