Non-Neoplastic Liver Pathology
A Pathologist’s Survival Guide
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Article
Open AccessApc-related models of intestinal neoplasia: a brief review for pathologists
Rodent models of intestinal cancer are widely used as preclinical models for human colorectal carcinoma and have proven useful in many experimental contexts, including elucidation of basic pathways of carcinog...
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Article
Open AccessActivation of EGFR-DNA-PKcs pathway by IGFBP2 protects esophageal adenocarcinoma cells from acidic bile salts-induced DNA damage
The incidence of esophageal adenocarcinoma (EAC) is rising rapidly in the US and Western countries. The development of Barrett’s esophagus (BE) and its progression to EAC have been linked to chronic gastroesop...
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Article
A precision oncology approach to the pharmacological targeting of mechanistic dependencies in neuroendocrine tumors
We introduce and validate a new precision oncology framework for the systematic prioritization of drugs targeting mechanistic tumor dependencies in individual patients. Compounds are prioritized on the basis o...
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Article
Open AccessCurrent applications of molecular pathology in colorectal carcinoma
Molecular pathology is playing an increasingly important role in the treatment and overall management of patients with colorectal carcinoma. Three distinct genetic pathways have been identified that play a rol...
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Article
Open AccessIntegrated molecular analysis reveals complex interactions between genomic and epigenomic alterations in esophageal adenocarcinomas
The incidence of esophageal adenocarcinoma (EAC) is rapidly rising in the United States and Western countries. In this study, we carried out an integrative molecular analysis to identify interactions between g...
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Book
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Chapter
Granulomas
Granulomatous hepatitis has many forms and causes (Fig. 9.1). Varieties of granuloma in the liver include epithelioid granulomas (non-caseating or caseating), necrotic palisading granulomas (i.e., abscessed or...
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Chapter
Sinusoidal Changes
Under normal circumstances, the hepatic sinusoids are inconspicuous and therefore often ignored. They usually come to attention when dilated, as the ga** spaces between the hepatocyte plates catch the eye (F...
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Chapter
Normal or Nearly Normal Liver
Not all liver specimens sent for pathologic examination will show histologic abnormalities. There are several situations that can lead to this. First, the patient may have no disease affecting the liver. This ...
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Chapter
Pigments and Inclusions
This chapter will cover a variety of mostly uncommon conditions that leave their mark by depositing material within the liver parenchyma. Some of this material is pigmented and can be quickly spotted, while ot...
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Chapter
Lobular Changes
Lobular injury comes in many forms and patterns. While it is often seen as a mild “background” component of chronic liver disease (Chap. 3), it can manifest as the primary pattern of injury in more acute proce...
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Chapter
Liver Transplantation
Certain disease states only (or almost only) occur in livers transplanted into a recipient patient. They generally represent immunologic phenomena or responses to surgical injury. The most common, and most ner...
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Chapter
Cholestasis
In anatomic pathology, cholestasis refers to microscopically visible bile in a section of liver tissue (Fig. 6.1). It can be present anywhere along the biliary tree, from hepatocellular canaliculi to small or ...
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Chapter
Special and Immunohistochemical Stains
H&E alone is rarely sufficient for a non-neoplastic liver sample. At a minimum, a trichrome stain should be ordered to assess for fibrosis unless the specimen is blatantly cirrhotic. A wide variety of other sp...
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Chapter
Fibrosis and Cirrhosis
This brief chapter will discuss usual and unusual patterns of fibrosis, along with approaches to cirrhosis in a patient without a known history of liver disease. Cirrhosis in the pediatric population is discus...
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Chapter
Introduction
Non-neoplastic liver pathology occupies an unusual niche in surgical pathology. Several other organs (such as the skin, brain, and kidney) demonstrate complex pathophysiological changes often requiring expert ...
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Chapter
Necrosis
Small foci of cell death (such as lobular apoptotic bodies) are commonly seen in inflammatory conditions. Some diseases, however, cause more widespread, confluent necrosis, destroying a large number of cells a...
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Chapter
Portal Inflammation
Portal inflammation is probably the most commonly observed pattern of liver injury (Fig. 3.1). Two major and common disease processes – chronic viral hepatitis and autoimmune hepatitis – are characterized by p...
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Chapter
Funny-Looking Cells
This chapter serves to cover various processes typified by unusual or “funny-looking” cells. Most cause this change in hepatocytes, but macrophages and stellate cells are sometimes involved. Proliferations of ...
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Chapter
Pediatric Liver Disease
This chapter covers diseases encountered more or less exclusively in the pediatric population. Liver samples from children, especially neonates, should be approached with these conditions in mind.
