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Protocol
Targeted Locus Amplification and Haploty**
Targeted locus amplification (TLA) allows for the detection of all genetic variation (including structural variation) in a genomic region of interest. As TLA is based on proximity ligation, variants can be lin...
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Article
Open AccessRobust detection of translocations in lymphoma FFPE samples using targeted locus capture-based sequencing
In routine diagnostic pathology, cancer biopsies are preserved by formalin-fixed, paraffin-embedding (FFPE) procedures for examination of (intra-) cellular morphology. Such procedures inadvertently induce DNA ...
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Article
Open AccessA generic workflow for Single Locus Sequence Ty** (SLST) design and subspecies characterization of microbiota
We present TaxPhlAn, a new method and bioinformatics pipeline for design and analysis of single-locus sequence ty** (SLST) markers to type and profile bacteria beyond the species-level in a complex microbial...
