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  1. No Access

    Article

    The effects of incorporation of the counterparts and mimics of l-lysine on the antimicrobial activity, hemolytic activity, cytotoxicity and tryptic stability of antimicrobial peptide polybia-MPII

    Due to the limited effects of conventional antibiotics on the increasing emergence of drug-resistant bacteria and fungi, novel antimicrobial agents were urgently needed to alleviate this phenomenon. Nowadays, ...

    **aolei Liang, Kexin Liu, ** Zhao, **g**g Zhou, Fangfang Zhang… in Amino Acids (2022)

  2. No Access

    Article

    Tryptic Stability and Antimicrobial Activity of the Derivatives of Polybia-CP with Fine-Tuning Modification in the Side Chain of Lysine

    Antimicrobial peptides (AMPs) were believed to be a class of promising antimicrobials to combat the increasing resistant microbes. However, AMPs could be easily degraded by endogenous proteases, which limited ...

    Feng**g Jia, **aolei Liang, Jiayi Wang… in International Journal of Peptide Research … (2021)

  3. No Access

    Article

    The introduction of l-phenylalanine into antimicrobial peptide protonectin enhances the selective antibacterial activity of its derivative phe-Prt against Gram-positive bacteria

    Protonectin was a typical amphiphilic antimicrobial peptide with potent antimicrobial activity against Gram-positive and Gram-negative bacteria. In the present study, when its eleventh amino acid in the sequen...

    **xiu Peng, Shuai Qiu, Feng**g Jia, Lishi Zhang, Yuhang He, Fangfang Zhang… in Amino Acids (2021)

  4. No Access

    Article

    Influence of Proline Substitution on the Bioactivity of Mammalian-Derived Antimicrobial Peptide NK-2

    Multidrug-resistant bacteria are emerging as a global threat, making the search for alternative compounds urgent. Antimicrobial peptides (AMPs) became a promising hotspot due to their distinct action mechanism...

    Jiexi Yan, **aolei Liang, Chang Liu, Yuemei Cheng… in Probiotics and Antimicrobial Proteins (2018)

  5. No Access

    Article

    The in vitro, in vivo antifungal activity and the action mode of Jelleine-I against Candida species

    Recently, the mortality of life-threatening fungal infections increased dramatically. However, there are few antifungals existed. Antimicrobial peptides (AMPs) as promising antifungal candidates have attracted...

    Feng**g Jia, Jiayi Wang, **xiu Peng, ** Zhao, Ziqing Kong, Kairong Wang… in Amino Acids (2018)

  6. Article

    Open Access

    Antimicrobial activity and stability of the d-amino acid substituted derivatives of antimicrobial peptide polybia-MPI

    Antimicrobial peptide has the potential to be developed as new kind of antimicrobial agents with novel action mechanism. However, the susceptibility to protease is a drawback for potential peptides to be clini...

    Yanyan Zhao, Min Zhang, Shuai Qiu, Jiayi Wang, **xiu Peng, ** Zhao… in AMB Express (2016)

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