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Article
Open AccessQuartet metabolite reference materials for inter-laboratory proficiency test and data integration of metabolomics profiling
Various laboratory-developed metabolomic methods lead to big challenges in inter-laboratory comparability and effective integration of diverse datasets.
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Article
Open AccessMulti-omics data integration using ratio-based quantitative profiling with Quartet reference materials
Characterization and integration of the genome, epigenome, transcriptome, proteome and metabolome of different datasets is difficult owing to a lack of ground truth. Here we develop and characterize suites of ...
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Protocol
Quantitative Analysis of Nucleoside Triphosphate Pools in Mouse Muscle Using Hydrophilic Interaction Liquid Chromatography Coupled with Tandem Mass Spectrometry Detection
Defects in deoxyribonucleoside triphosphate (dNTP) metabolism are associated with a number of mitochondrial DNA (mtDNA) depletion syndromes (MDS). These disorders affect the muscles, liver, and brain, and the ...
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Article
Open AccessEnhanced inflammation and suppressed adaptive immunity in COVID-19 with prolonged RNA shedding
Little is known regarding why a subset of COVID-19 patients exhibited prolonged positivity of SARS-CoV-2 infection. Here, we found that patients with long viral RNA course (LC) exhibited prolonged high-level I...
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Article
The in vitro, in vivo antifungal activity and the action mode of Jelleine-I against Candida species
Recently, the mortality of life-threatening fungal infections increased dramatically. However, there are few antifungals existed. Antimicrobial peptides (AMPs) as promising antifungal candidates have attracted...
