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Article
Prolonged glucose infusion into conscious rats inhibits early steps in insulin signalling and induces translocation of GLUT4 and protein kinase C in skeletal muscle
Previous studies on diabetic patients have shown that hyperglycaemia increases glucose uptake in an apparently insulin-independent manner. However, the molecular mechanism has not been clarified.
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Article
The tumour necrosis factor alpha –238 G → A and –308 G → A promoter polymorphisms are not associated with insulin sensitivity and insulin secretion in young healthy relatives of Type II Diabetic patients
Aims/hypothesis. Tumour necrosis factor-α (TNF-α) is believed to influence skeletal muscle insulin resistance. Two G → A transitions in the promoter region of TNF- α at position –...
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Article
Effect of obesity and insulin resistance on resting and glucose-induced thermogenesis in man
OBJECTIVE: to assess the impact of obesity and insulin sensitivity on resting (REE) and glucose-induced thermo-genesis (GIT).
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Article
Lipolysis in skeletal muscle is rapidly regulated by low physiological doses of insulin
Aims/hypothesis. Both patients with Type II (non-insulin-dependent) diabetes mellitus and normoglycaemic, insulin resistant subjects were shown to have an increased lipid content in skeletal musc...
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Article
35th Annual Meeting of the European Association for the Study of Diabetes
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Article
The PPARγ2 amino acid polymorphism Pro 12 Ala is prevalent in offspring of Type II diabetic patients and is associated to increased insulin sensitivity in a subgroup of obese subjects
Aims/hypothesis. Recently a mutation in the coding sequence of the adipocyte specific isoform peroxisome proliferator-activated receptor γ2 (PPARγ2) was described, leading to the substitution of ...
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Article
Insulin-induced translocation of GLUT 4 in skeletal muscle of insulin-resistant Zucker rats
The genetically obese Zucker rat (fa/fa) is an animal model with severe insulin resistance of the skeletal muscle. We investigated whether a defect of insulin-dependent glucose transporter (GLUT 4) translocati...
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Article
Normal insulin receptor tyrosine kinase activity and glucose transporter (GLUT 4) levels in the skeletal muscle of hyperinsulinaemic hypertensive rats
The spontaneous hypertensive rat is an animal model characterized by a syndrome of hypertension, insulin resistance and hyperinsulinaemia. To elucidate whether in analogy to other insulin resistant animal mode...
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Chapter
Dose — Dependent Effects of Bradykinin Infusion in Postoperative Patients
The physiologoical role of locally liberated bradykinin from tissue kallikrein is still not known.The kallikrein-kinin system may be involved in many functions as vascular tone and blood pressure regulation,sa...
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Chapter
Increased Insulin-Responsiveness by Ace-Inhibition in Non-Insulin Dependent Diabetes Mellitus
The classical pharmacological actions of kinins that occur at umol and higher concentrations comprise the interaction with pain receptors, stimulation of smooth muscle contraction, vasodilatation and an increa...
