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Long-term and rapid regulation of ob mRNA levels in adipose tissue from normal (Sprague Dawley rats) and obese [db/db mice, fa/fa rats) rodents
Increased levels of mRNA transcribed from the ob gene in adipose tissue of obese/hyperin-sulinaemic Zucker (fa/fa) rats were detectable as early as 3 weeks after birth and continued to rise there after in paralle...
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Article
Impaired FAD-glycerophosphate dehydrogenase activity in islet and liver homogenates of fa/fa rats
The mitochondrial FAD-linked enzyme glycerophosphate dehydrogenase plays a key role in the pancreatic B-cell glucose sensing device. In the present study, the activity of this enzyme was examined in islets of ...
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Article
Insulin-induced translocation of GLUT 4 in skeletal muscle of insulin-resistant Zucker rats
The genetically obese Zucker rat (fa/fa) is an animal model with severe insulin resistance of the skeletal muscle. We investigated whether a defect of insulin-dependent glucose transporter (GLUT 4) translocati...
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Article
A multiplicity of protein antigens in subcellular fractions of rat insulinoma tissue are able to stimulate T cells obtained from non-obese diabetic mice
Type 1 (insulin-dependent) diabetes mellitus is a T-cell mediated autoimmune disease with a number of different proteins being implicated as target autoantigens. A 38 kDa protein residing in the insulin secret...
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Article
Persistent MHV (mouse hepatitis virus) infection reduces the incidence of diabetes mellitus in non-obese diabetic mice
The frequency of diabetes mellitus was compared in non-obese diabetic mice before and after inadvertent exposure of the colony to mouse hepatitis virus infection. Prior to exposure, diabetes prevalence and cum...
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Article
Gangliosides in vivo reduce diabetes incidence in non-obese diabetic mice
Non-obese diabetic mice were treated daily with a mixture of ganliosides from day 30 until day 250 of life or until the mice became diabetic. Ganglioside treatment reduced diabetes incidence from 80–90% to 47%...
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Article
Irish Endocrine Society
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Article
Treadmill training improves intravenous glucose tolerance and insulin sensitivity in fatty zucker rats
The effect of treadmill training on intravenous glucose tolerance and insulin sensitivity was investigated in Zucker rats (fafa). In 25-week-old fafa animals with the typical metabolic syndrome of massive obes...
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Article
Effect of physical training on glucose tolerance and on glucose metabolism of skeletal muscle in anaesthetized normal rats
The effect of physical training on glucose tolerance in vivo and skeletal muscle glucose metabolism in vitro was investigated in normal rats. Treadmill running for 10 days up to 240 min/day led to a decrease o...
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Book
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Article
Eighth annual meeting of the European Association for the Study of Diabetes
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Seventh Annual Meeting of the European Association for the Study of Diabetes
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Seventh Annual Meeting of the European Association for the Study Of Diabetes Southampton, England, September 15–17, 1971 Abstacts, Part 1
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Article
Regulation of glycerol kinase by insulin in isolated fat cells and liver of Bar Harbor Obese Mice
Glycerol kinase was measured by a modification of the radiochemical enzyme test described by Newsholme and coworkers in isolated epididymal and parametrial fat cells and liver tissue of obese hyperglycaemic Ba...
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Article
Effect of weight and cell size on hormone-induced lipolysis in New Zealand obese mice and American obese hyperglycemic micce
In NZO mice fat cell size is strongly correlated to increasing body weight; FFA and glycerol release from adipose tissue under basal conditions and after stimulation with norepinephrine, ACTH, DB-cyclic AMP an...
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Article
Differences in the development of the obese-hyperglycemic syndrome in obob and NZO mice
Marked differences were shown in the development of the obese-hyperglycemic syndrome in NZO andobob mice. — In NZO mice glucose tolerance decreases continuously with increasing age and body weight. — Inobob mice ...
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Article
Über die Veränderung von Aminosäuren, Blutzucker, Glucocorticoiden, freien Fettsäuren und freiem Glycerin im Plasma nach Insulininjektion mit und ohne Infusion von Aminosäuren
An 4 gesunden jungen Männern wurden Belastungsversuche mit Insulin, mit Aminosäuren, sowie mit Insulin und Aminosäuren über die Zeit von 3 Std durchgeführt. Folgende Parameter wurden vor und im Abstand von 15 ...
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Article
3. Kongreß der Deutschen Diabetes-Gesellschaft
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Article
Das Verhalten der freien Fettsäuren unter intravenöser Glucosebelastung bei graviden und nicht graviden Patientinnen mit Symptomen eines potentiellen Diabetes mellitus
In 97 women (aged 18–52 years) blood glucose and nonesterified fatty acids were determined before and following a rapid intravenous injection of 25 g glucose (50 ml, 50% solution). 49 of these women were pregn...
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Chapter
Der Einfluß der Metopirondosis auf die Corticosteroidausscheidung in Abhängigkeit vom Körpergewicht
In persons without endocrine, hepatic or renal disease a study of urinary steroid excretion was carried out under various doses of metyrapone. After 250 mg every 2 hours for 12 doses as well as after 70 mg kg ...
