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Chapter
Boswellic Acids and Their Role in Chronic Inflammatory Diseases
Boswellic acids, which are pentacyclic triterpenes belong to the active pharmacological compounds of the oleogum resin of different Boswellia species. In the resin, more than 12 different boswellic acids have ...
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Article
Glucose oversupply increases Δ9-desaturase expression and its metabolites in rat skeletal muscle
Previous studies have shown that prolonged glucose infusion causes insulin resistance and triglyceride accumulation in rat skeletal muscle. In this study, we investigated a possible relationship between insuli...
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Article
Prolonged glucose infusion into conscious rats inhibits early steps in insulin signalling and induces translocation of GLUT4 and protein kinase C in skeletal muscle
Previous studies on diabetic patients have shown that hyperglycaemia increases glucose uptake in an apparently insulin-independent manner. However, the molecular mechanism has not been clarified.
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Article
35th Annual Meeting of the European Association for the Study of Diabetes
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Article
Open AccessBoswellic acids and malignant glioma: induction of apoptosis but no modulation of drug sensitivity
Steroids are essential for the control of oedema in human malignant glioma patients but may interfere with the efficacy of chemotherapy. Boswellic acids are phytotherapeutic anti-inflammatory agents that may b...
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Article
The phosphatase inhibitor okadaic acid blocks KCl-depolarization-induced rise of cytosolic calcium of rat insulinoma cells (RINm5F)
It has been shown that okadaic acid (OA) diminishes insulin secretion of rat pancreatic islets in response to glucose, glyceraldehyde and KCl. Glucose, glyceraldehyde and KCl cause release of insulin by depola...
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Chapter and Conference Paper
Islet redox state, calcium uptake and insulin secretion: Effects of old age and oxidative stress
Since the establishment of methods for the isolation of viable pancreatic islets (Hellerström, 1964; Moskalewski, 1965; Keen et al., 1965; Lacy and Kostianovsky, 1967) extensive work has been performed to stud...
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Article
Vasoactive intestinal polypeptide-augmented insulin release: actions on ionic fluxes and electrical activity of mouse islets
Vasoactive intestinal polypeptide is a pancreatic neurotransmitter which augments insulin release. To obtain more detailed information on its mode of action on the pancreatic beta cell we studied the effect of...
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Article
KCl-induced insulin secretion from RINm5F cells is mediated through Ca2+ influx along L-type Ca2+ channels
In order to characterize the voltage-dependent Ca2+ channels of insulin secretory RINm 5F cells, we have studied the binding of the dihydropyridine (DHP) type Ca2+ antagonist PN 200-110 and its effect on insulin ...
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Article
A possible role of plasma glutathione in glucose-mediated insulin secretion: in vitro and in vivo studies in rats
In isolated rat pancreatic islets exogenous glutathione which is not able to penetrate into cells, augmented glucose (11.1 mmol/l)-mediated insulin release. In the presence of a non-stimulatory glucose concent...
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Article
Cholecystokinin (CCK8) regulates glucagon, insulin, and somatostatin secretion from isolated rat pancreatic islets: interaction with glucose
The effect of CCK8 on glucagon, insulin and somatostatin release and its interaction with glucose was studied in freshly isolated rat pancreatic islets. While glucose alone inhibited glucagon secretion [half-maxi...
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Article
Effects of propylthiouracil and methylthiouracil on cyclic AMP and ion movements in rat pancreatic islets
Propylthiouracil and methylthiouracil have been shown to potentiate glucose-induced insulin secretion from rat pancreatic islets: the effect of methylthiouracil being less pronounced than that of propylthioura...
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Article
Effect of forskolin on islet cyclic AMP, insulin secretion, blood glucose and intravenous glucose tolerance in rats
The in vivo effect of forskolin on insulin release, blood glucose and intravenous glucose tolerance test has been studied in the rat. In addition in vitro experiments on the effect of forskolin on islet cAMP a...
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Article
Potentiation of glucose-induced insulin release by thiourea and thiourea derivatives
The effect of thiourea and its derivatives, including methyl- and propylthiouracil as well as the imidazole derivative thiamazole on glucose-induced insulin secretion from incubated rat pancreatic islets was s...
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Article
Effect of diamide and reduced glutathione on the elevated levels of cyclic AMP in rat pancreatic islets exposed to glucose, p-chloromercuribenzoate and aminophylline
In rat pancreatic islets the effects of diamide, which has been shown to decrease islet levels of reduced glutathione (GSH), and of exogenous GSH were investigated on cyclic AMP as increased by glucose, p-chlo...
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Article
Potentiation of the insulin-releasing capacity of tolbutamide by thiols: Studies on the isolated perfused pancreas
It has been suggested that the islet thiol redox status plays a role in the regulation of β-cell sensitivity in response to insulin secretagogues. Employing the isolated perfused rat pancreas, the effect of reduc...
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Article
Effect of Methylene Blue on pyridine nucleotides and insulin secretion of rat pancreatic islets
Methylene Blue, which is known to oxidise NADPH in red blood cells, was used to assess a possible role of NADPH in the glucose-stimulated secretion of insulin. When islets from rats were incubated with 3 mg/ml...
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Article
Effect of methylene blue and thiol oxidants on pancreatic islet GSH/GSSG ratios and tolbutamide mediated insulin release in vitro
Methylene blue (an oxidant of NADPH), diamide (an oxidant of glutathion-SH [GSH]) and tertbutyl hydroperoxide (a substrate of glutathione peroxidase) significantly decreased the GSH content of pancreatic rat i...
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Chapter
Specific Binding of [125J] insulin to Isolated Pancreatic Islets of Rats and Its Relationship to Glucose Metabolism
Exogenous insulin has been shown to decrease islet pentosephosphate shunt (PPS) activity, NADPH/NADP ratio and glucose induced insulin release. It was now studied whether insulin specifically binds to pancreat...
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Article
Swimming capacity of mice after prolonged treatment with psychostimulants
A comparative study of the effects of a single dose of caffeine (50 μg/g s.c.) and of 6-weeks treatment with 150 μg/g p.o. caffeine/day on swimming capacity and resistance to cold exposure was performed in mic...
