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Article
Prolonged glucose infusion into conscious rats inhibits early steps in insulin signalling and induces translocation of GLUT4 and protein kinase C in skeletal muscle
Previous studies on diabetic patients have shown that hyperglycaemia increases glucose uptake in an apparently insulin-independent manner. However, the molecular mechanism has not been clarified.
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Article
The tumour necrosis factor alpha –238 G → A and –308 G → A promoter polymorphisms are not associated with insulin sensitivity and insulin secretion in young healthy relatives of Type II Diabetic patients
Aims/hypothesis. Tumour necrosis factor-α (TNF-α) is believed to influence skeletal muscle insulin resistance. Two G → A transitions in the promoter region of TNF- α at position –...
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Article
Effect of obesity and insulin resistance on resting and glucose-induced thermogenesis in man
OBJECTIVE: to assess the impact of obesity and insulin sensitivity on resting (REE) and glucose-induced thermo-genesis (GIT).
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Article
Lipolysis in skeletal muscle is rapidly regulated by low physiological doses of insulin
Aims/hypothesis. Both patients with Type II (non-insulin-dependent) diabetes mellitus and normoglycaemic, insulin resistant subjects were shown to have an increased lipid content in skeletal musc...
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Article
35th Annual Meeting of the European Association for the Study of Diabetes
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Article
The PPARγ2 amino acid polymorphism Pro 12 Ala is prevalent in offspring of Type II diabetic patients and is associated to increased insulin sensitivity in a subgroup of obese subjects
Aims/hypothesis. Recently a mutation in the coding sequence of the adipocyte specific isoform peroxisome proliferator-activated receptor γ2 (PPARγ2) was described, leading to the substitution of ...
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Article
Insulin-induced translocation of GLUT 4 in skeletal muscle of insulin-resistant Zucker rats
The genetically obese Zucker rat (fa/fa) is an animal model with severe insulin resistance of the skeletal muscle. We investigated whether a defect of insulin-dependent glucose transporter (GLUT 4) translocati...
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Article
Normal insulin receptor tyrosine kinase activity and glucose transporter (GLUT 4) levels in the skeletal muscle of hyperinsulinaemic hypertensive rats
The spontaneous hypertensive rat is an animal model characterized by a syndrome of hypertension, insulin resistance and hyperinsulinaemia. To elucidate whether in analogy to other insulin resistant animal mode...
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Chapter
Stoffwechseleffekte von Prostaglandin E1 auf den menschlichen Skelettmuskel
Das therapeutische Prinzip in der Behandlung einer auf dem Boden einer obliterierenden Angiopathie durch Ischämie bedrohten Extremität beruht im Versuch einer Revaskularisierung, wann immer dies möglich ersche...
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Article
353. Der Muskelstoffwechsel unter dem Einfluß von Fettinfusionen
In 12 volunteers and in 15 patients recovering from abdominal surgery, we investigated the effect of a fat infusion containing middle-chain triglyceride (MCT) or long-chain triglycerides (LCT) on skeletal musc...
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Chapter and Conference Paper
Postersession III
Diabetes mellitus (DM) ist ein klinisches Syndrom, dessen Häufigkeit in den westlichen Industriestaaten auf 1,5–2,5% geschätzt wird [1] und dessen Prävalenz genetisch bedingt in manchen Populationen (Pima-Indi...