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  1. No Access

    Chapter

    Cellular and Metabolic Significance of Cellular Acid-Base Shifts in Human Stroke

    Stroke is most often due to the occlusion of a single intracranial artery, resulting in incomplete focal ischemia. This has an immediate deleterious effect upon cerebral energy metabolism and dependent process...

    K. M. A. Welch, Steven R. Levine… in Neurochemical Correlates of Cerebral Ische… (1992)

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    Article

    Chronic changes in brain Mg2+ concentration after forebrain ischemia in the rat

    Brain Mg2+ ion concentrations, [Mg2+], were evaluated in three groups of animals subjected to either 8 minutes (n=10), or 12 minutes (n=10) of near-complete forebrain ischemia, or sham operation (n=10), from thei...

    Ana M. Q. Vande Linde, Michael Chopp, Hua Chen, J. A. Helpern… in Metabolic Brain Disease (1991)

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    Chapter

    Magnetic Observation of Spreading Cortical Depression in Anaesthetized Rabbits

    Spreading depression (SD) is a profound disturbance of the environment of brain cells that occurs as a stereotyped response to several types of strong stimulation or trauma (for reviews see e.g. Bures et al., ...

    A. R. Gardner-Medwin, N. Tepley, G. L. Barkley, J. Moran… in Advances in Biomagnetism (1989)

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    Chapter

    Observation of Spreading Cortical Depression in Migraine Patients

    Spreading cortical depression (SCD) in animal models was first described by Leao [1] in 1944. SCD, although never observed spontaneously in humans, has been implicated in migraine for a variety of reasons: 1) ...

    N. Tepley, G. L. Barkley, J. E. Moran, R. T. Simkins… in Advances in Biomagnetism (1989)

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    Chapter

    The Influence of Serotonin on Seizure Susceptibility in the Gerbil

    5-hydroxytryptophan (5-HTP) (50 mg/kg, I.P.) increased central serotonin (5-HT) levels and delayed the onset of seizure during reflow in gerbils subjected to transient bilateral blockade with dimethyl tryptami...

    K. M. A. Welch, Janes C. H. Chan, Eva Chabi… in Pathophysiology of Cerebral Energy Metabol… (1979)

  6. No Access

    Chapter

    Reemphasis of the Role of 5-Hydroxytryptamine in Cerebral Ischemia

    Cortical monoamine changes during ischemic episodes of up to one hour were studied in the gerbil. Norepinephrine (NE) levels decreased after 60 minutes in the occluded hemisphere of animals with stroke, but do...

    K. M. A. Welch, Eva Chabi, R. J. Gaudet… in Pathophysiology of Cerebral Energy Metabol… (1979)