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Article
Forewarning of hypotensive events using a Bayesian artificial neural network in neurocritical care
Traumatically brain injured (TBI) patients are at risk from secondary insults. Arterial hypotension, critically low blood pressure, is one of the most dangerous secondary insults and is related to poor outcome...
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Chapter and Conference Paper
KidsBrainIT: A New Multi-centre, Multi-disciplinary, Multi-national Paediatric Brain Monitoring Collaboration
Objectives: Validated optimal cerebral perfusion pressure (CPP) treatment thresholds in children do not exist. To improve the intensive care unit (ICU) management of the paediatric traumatic brain injury (TBI) p...
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Chapter
Influence of Isoflurane on Neuronal Death and Outcome in a Rat Model of Traumatic Brain Injury
In the develo** brain agents clinically used for the purpose of analgosedation can cause severe neurodegeneration. In patients with TBI analgosedation is a first-line treatment for intracranial hypertension....
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Chapter
Trigger Characteristics of EUSIG-Defined Hypotensive Events
Background: Hypotension is a recognized secondary insult after traumatic brain injury (TBI). There are many definitions of hypotension, an often cited example being the Brain Trauma Foundation’s c...
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Chapter
Early Warning of EUSIG-Defined Hypotensive Events Using a Bayesian Artificial Neural Network
Background: Hypotension is recognized as a potentially damaging secondary insult after traumatic brain injury. Systems to give clinical teams some early warning of likely hypotensive instability co...
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Article
Neurochirurgische Standards bei tiefer Hirnstimulation
Voraussetzung für die therapeutische Anwendung der tiefen Hirnstimulation (THS) ist eine stereotaktisch-neurochirurgische Operation mit Implantation von Hirnelektroden in subkortikale Zielstrukturen des Gehirn...
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Article
Neurochemical Monitoring of Therapeutic Effects in Large Human MCA Infarction
Cerebral microdialysis is an invasive monitoring tool allowing analysis of various substances derived from the extracellular space in brain tissue such as glutamate, glycerol, lactate, and pyruvate. In order t...
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Article
The use of hyperventilation therapy after traumatic brain injury in Europe: an analysis of the BrainIT database
To assess the use of hyperventilation and the adherence to Brain Trauma Foundation-Guidelines (BTF-G) after traumatic brain injury (TBI).
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Article
Aquaporin 4 regulation during acute and long-term experimental Herpes simplex virus encephalitis
Structural damage of the central nervous system (CNS) often leads to severely disabling residual symptoms despite effective antiviral therapy during Herpes simplex virus encephalitis (HSVE). Edematous space-oc...
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Chapter and Conference Paper
BrainIT: a trans-national head injury monitoring research network
Studies of therapeutic interventions and management strategies on head injured patients are difficult to undertake. BrainIT provides validated data for analysis available to centers that contribute data to all...
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Article
Continuous cerebral compliance monitoring in severe head injury: its relationship with intracranial pressure and cerebral perfusion pressure
Background. Cerebral compliance expresses the capability to buffer an intracranial volume increase while avoiding a rise in intracranial pressure (ICP). The autoregulatory response to Cerebral Perfusion Pressure ...
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Chapter and Conference Paper
Survey of traumatic brain injury management in European Brain-IT centres year 2001
The aim of this study was to obtain basic knowledge about the current local conditions and neurointensive care of traumatic brain injury (TBI) in the new multi-centre collaborative BrainIT group.
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Chapter and Conference Paper
The BrainIT Group: concept and current status 2004
An open collaborative international network has been established which aims to improve inter-centre standards for collection of high-resolution, neurointensive care data on patients with traumatic brain injury...
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Chapter and Conference Paper
Accurate data collection for head injury monitoring studies: a data validation methodology
BrainIT is a multi centre, European project, to collect high quality continuous data from severely head injured patients using a previously defined [6] core data set. This includes minute-by-minute physiologic...
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Article
R3-Survey of traumatic brain injury management in European Brain IT centres year 2001
To obtain knowledge about the conditions and management of traumatic brain injury (TBI) in a collaborative network of Brain Information Technology centres.
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Article
The BrainIT group: concept and core dataset definition
¶Introduction. An open collaborative international network has been established which aims to improve inter-centre standards for collection of high-resolution, neurointensive care data on patients with traumatic ...
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Chapter and Conference Paper
Multi-Centre Assessment of the Spiegelberg Compliance Monitor: Interim Results
Analyses of a multi-centre database of 71 patients at risk of raised ICP showed that in head injured patients (n = 19) and tumour patients (n = 13) clear inverse relationships of ICP vs compliance exist. SAH p...
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Chapter and Conference Paper
Multi-Centre Assessment of the Spiegelberg Compliance Monitor: Preliminary Results
Acute brain injury states (eg. head injury, subarachnoid haemorrhage) show clear inverse relationships of ICP vs compliance, with ICP instability at times of lower compliance states. Variance in compliance val...
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Article
Oxymetrie im Bulbus jugularis bei komatösen Patienten
Das Monitoring der Sauerstoffsättigung im Bulbus venae jugularis (auch Bulbusoxymetrie genannt) ist eine Methode zur kontinuierlichen Erfassung der globalen zerebrovenösen Sauerstoffsättigung (SjvO2). Diese kan...
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Chapter and Conference Paper
Validation of Monitoring of Cerebral Oxygenation by Near-Infrared Spectroscopy in Comatose Patients
Secondary ischemic brain damage is a common event in patients with severe brain injuries, and is often verified at autopsy, for example, following severe head injury. It is widely accepted that secondary brain...
