-
Article
Open AccessAn explorative single-arm clinical study to assess craving in patients with alcohol use disorder using Virtual Reality exposure (CRAVE)—study protocol
Alcohol use disorder (AUD) belongs to the most burdensome clinical disorders worldwide. Current treatment approaches yield unsatisfactory long-term effects with relapse rates up to 85%. Craving for alcohol is ...
-
Chapter
Case 24. Extranodal NK/T-Cell lymphoma, nasal type
NK/T-cell lymphomas are extremely rare lymphomas in the western world. The population of CD3+CD56+ NK/T-cells that seems to be the progenitor cells for those types of lymphomas is not homogeneous, which may ex...
-
Article
Open Access(Neuro)therapeutic Approaches in the Field of Alcohol Use Disorders
Alcohol use disorder (AUD) is a burdening chronic condition that is characterized by high relapse rates despite severe negative consequences. There has been a recent emergence of interest in (neuro)therapeutic...
-
Article
Viability of Probiotics in Goat Cheese During Storage and Under Simulated Gastrointestinal Conditions
The objective of this study was to evaluate the suitability of two strains of probiotic bacteria (Bifidobacterium animalis subsp. lactis and Lactobacillus rhamnosus) incorporated individually into Boursin-type go...
-
Article
Open AccessRedox preconditioning deep cratonic lithosphere for kimberlite genesis – evidence from the central Slave Craton
We present the first oxygen fugacity (fO2) profile through the cratonic lithospheric mantle under the Panda kimberlite (Ekati Diamond Mine) in the Lac de Gras kimberlite field, central Slave Craton, northern Cana...
-
Article
Open AccessFlow cytometry defined cytoplasmic immunoglobulin index is a major prognostic factor for progression of asymptomatic monoclonal gammopathies to multiple myeloma (subset analysis of SWOG S0120)
-
Article
Clinical value of molecular subty** multiple myeloma using gene expression profiling
Using a data set of 1217 patients with multiple myeloma enrolled in Total Therapies, we have examined the impact of novel therapies on molecular and risk subgroups and the clinical value of molecular classific...
-
Article
Open AccessCarfilzomib and the cardiorenal system in myeloma: an endothelial effect?
Carfilzomib (Cfz) has been associated with an ~5% incidence of unexplained and unpredictable cardiovascular toxicity in clinical trials. We therefore implemented a detailed, prospective, clinical cardiac and r...
-
Article
Open AccessThe flow cytometry-defined light chain cytoplasmic immunoglobulin index and an associated 12-gene expression signature are independent prognostic factors in multiple myeloma
As part of Total Therapy (TT) 3b, baseline marrow aspirates were subjected to two-color flow cytometry of nuclear DNA content and cytoplasmic immunoglobulin (DNA/CIG) as well as plasma cell gene expression pro...
-
Article
Consumer Sensory Characterization of Cooked Ham Using the Check-All-That-Apply (CATA) Methodology
The check-all-that-apply (CATA) methodology was created because of the need to develop a reliable and rapid method for sensory characterization of products due to difficulties in the food industry in routinely ap...
-
Article
Open AccessRenal insufficiency retains adverse prognostic implications despite renal function improvement following Total Therapy for newly diagnosed multiple myeloma
Renal insufficiency (RI) is a frequent complication of multiple myeloma (MM) with negative consequences for patient survival. The improved clinical outcome with successive Total Therapy (TT) protocols was limi...
-
Chapter
Modulation of Neurotrophin Signaling by Monoclonal Antibodies
The neurotrophin family is comprised of the structurally related secreted proteins nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophine-4 (NT-4). They b...
-
Article
Psychische Faktoren bei Magenbandimplantation
Adipositas ist eine weit verbreitete Krankheit in den westlichen Industrieländern, die hohe krankheitsbedingte Kosten verursacht. Verschiedene größere Studien konnten positive Effekte einer chirurgischen Adipo...
-
Article
Sequence analysis of a DNA fragment fromSinorhizobium fredii USDA257 which extends the nitrogen fixation host range ofRhizobium species NGR234 to soybean,Glycine max (L.) Merr cultivar Peking
A fragment of DNA (pBTBX) from the genome ofSinorhizobium fredii USDA257 was sequenced by shotgun strategy to identify the potential genes which enabled theRhizobium species NGR234 to fix nitrogen on soybean,Glyc...
-
Chapter and Conference Paper
Multispectral Optoacoustic Tomography (MSOT) Characterization in Resolving Molecular Biomarkers
Fluorochromes are essential biological reporters in many areas of biomedical research and, in particular, molecular imaging applications. We demonstrate the basic performance characteristics of multispectral o...
-
Chapter and Conference Paper
Free-Choice Profiling of Passion Fruit Juice Processed by High Hydrostatic Pressure
High hydrostatic pressure (HHP) refers to the process that subjects food to pressures ranging from 100 MPa to 900 MPa and, in commercial systems, between 300 MPa and 700 MPa (San Martín et al., 2002). The use ...
-
Article
Differential expression of genes encoding tight junction proteins in colorectal cancer: frequent dysregulation of claudin-1, -8 and -12
As integral membrane proteins, claudins form tight junctions together with occludin. Several claudins were shown to be up-regulated in various cancer types. We performed an expression analysis of genes encodin...
-
Article
The genome of the social amoeba Dictyostelium discoideum
The social amoebae are exceptional in their ability to alternate between unicellular and multicellular forms. Here we describe the genome of the best-studied member of this group, Dictyostelium discoideum. The ge...
-
Article
Non-invasive computerised detection of acute coronary occlusion
The goal of this study was to evaluate the role of a computerised, non-invasive ECG method for detecting acute coronary occlusion (ACO). Ninety-five standard ECG leads were recorded, before and during ACO, fro...
-
Chapter
Clinical Experience Using the SurgiGATE System
Anterior cruciate ligament (ACL) reconstruction occurs most commonly in the young and active patient 13,10,20]. The frequency of ACL injuries has increased because recreational activities and more risky sports...
