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Article
Prognostic significance of molecular staging by PCR-amplification of immunoglobulin gene rearrangements in diffuse large B-cell lymphoma (DLBCL)
The prognostic value of the detection of peripheral blood (PB) and/or bone marrow (BM) involvement by polymerase chain reaction (PCR) amplification of rearranged immunoglobulin heavy chain (IgH) and immunoglob...
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Chapter
Osteosarkom
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Chapter
Osteosarkom
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Chapter
Osteosarkom
Osteosarkome betreffen 0,1% aller Krebserkrankungen und 2,8% der Krebserkrankungen unter 15 Jahren.
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Chapter
Osteosarkom
Das Osteosarkom ist der zweithäufigste primär maligne Knochentumor. Sein Anteil an den Krebserkrankungen insgesamt liegt jedoch bei nur 0,1%. Die jährliche Inzidenz beträgt 2–3 pro 106 Bevölkerung, d.h. in der BR...
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Chapter and Conference Paper
Conserved Cytotoxic Activity of Aclacinomycin A in Multifactorial Multidrug Resistance
Identification of anthracyclines which are able to overcome multidrug resistance would be a major step towards to improving antineoplastic chemotherapy.
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Chapter and Conference Paper
Prognostic Significance of Exposure to Intermediate-Dose Methotrexate in Children with Standard Risk ALL: The COALL 82/85 Experience
Methotrexate is being widely used in doses ranging from 500 to 2 000 mg administered as prolonged infusion over 12–36 h followed by leucovorin rescue to consolidate remission of acute lymphoblastic leukemia [1...
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Chapter and Conference Paper
Bone Marrow Blast Count at Day 28 as the Single Most Important Prognostic Factor in Childhood Acute Lymphoblastic Leukemia
Intensification of therapy and risk-adapted treatment have increased the cure rates for childhood acute lymphocytic leukemia (ALL) to 60%–70% [1–5]. Among the prognostic parameters the initial white blood coun...
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Chapter and Conference Paper
Improved Prognosis for Childhood Acute Lymphocytic Leukemia with Very High White Blood Cell Count (> 100/nl) with Rotation of Non-Cross-Resistant Drug Combinations
Among several initial prognostic factors in acute lymphoblastic leukemia (ALL), i.e., age, hepatosplenomegaly, immunologic subtype, and chromosomal abnormalities [1–4], an elevated white blood count (WBC) at d...
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Article
High-dose ifosfamide with mesna uroprotection in Ewing's sarcoma
The German Society of Pediatric Oncology (GPO) has studied the efficacy of high-dose ifosfamide with mesna uroprotection in patients with Ewing's sarcoma. A phase II trial of ifosfamide (IFO) (2 g/m2 per day, day...
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Chapter
The German Pediatric Oncology (GPO) Cooperative Study on Ewing’s Sarcoma
In 1981, the GPO cooperative Ewing’s Sarcoma study (CESS-81) was initiated (1). Patients under the age of 25, with histologically proven diagnosis and without evidence of metastases, received four 9-week cycle...
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Chapter
The German Pediatric Oncology (GPO) Cooperative Study on Osteosarcoma
The GPO has conducted a consecutive series of adjuvant chemotherapy trials in osteosarcoma of the extremities since 1977. Figure 1 shows the outline of the chemotherapy, and Table 1 the global outcome of the d...
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Chapter
Results of the German Soft-Tissue Sarcoma Study
Between 1981 and the end of 1985, 352 children and teenagers with all types of soft-tissue sarcomas were registered in a national multi-center study. Of these, 293 patients were classified under chemosensitive...
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Chapter and Conference Paper
Early Intensification Therapy in High-Risk Childhood Acute Lymphocytic Leukemia: Lack of Benefit from High-Dose Methotrexate
The prognosis for acute lymphoblastic leukemia (ALL) in childhood has improved considerably in the last two decades. Intensive chemotherapy soon after diagnosis has made a major contribution to this success [3...
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Article
CPO—Cooperative ewing's sarcoma study 1981 (CESS 81): Results after 4 years
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Article
Response kinetic under initial cytostatic treatment according to prognosis of phabdomyosarcoma — A report from the CWS-81 study of the german society of pediatric oncology (GPO)
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Article
Conclusions from the cooperative osteosarcoma (OS) studies COSS-80 and COSS-82 for future therapeutic strategies
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Article
Effectiveness of ifosfamide (IFO) alone and in combination with cisplatinum (DDP) in patients with recurrent ewing's sarcoma
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Chapter and Conference Paper
Myelolactoferrin Index (MLF) and Myelopoiesis During Bacterial Infections and Malignant Diseases
The myelolactoferrin index (MLF) is significantly lowered in patients with bacterial infections and with malignant diseases. In both cases it can be assumed that the alteration of the granulopoietic storage po...
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Article
Adjuvant chemotherapy in osteosarcoma — Effects of cisplatinum, BCD, and fibroblast interferon in sequential combination with HD-MTX and adriamycin
In a cooperative adjuvant chemotherapy study of osteosarcoma (COSS-80), 192 patients were registered from December 1979 to March 1982. Fortyone patients have been excluded from study because of their nonadjuva...
