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Article
Conclusions from the cooperative osteosarcoma (OS) studies COSS-80 and COSS-82 for future therapeutic strategies
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Article
Adjuvant chemotherapy in osteosarcoma — Effects of cisplatinum, BCD, and fibroblast interferon in sequential combination with HD-MTX and adriamycin
In a cooperative adjuvant chemotherapy study of osteosarcoma (COSS-80), 192 patients were registered from December 1979 to March 1982. Fortyone patients have been excluded from study because of their nonadjuva...
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Article
Toxicity associated with combination chemotherapy for osteosarcoma: A report of the cooperative osteosarcoma study (COSS 80)
The treatment-associated toxicity in 189 patients entered in the COSS-80 Study was analyzed. The sequential use of high-dose methotrexate (HDMTX) with citrovorum factor rescue (CFR) andcis-platinum may be additiv...
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Article
Morphological grades of regression in osteosarcoma after polychemotherapy — Study COSS 80
The histologic grade of regression of 50 osteosarcomas after polychemotherapy — according to the protocol study, COSS 80 — was classified on a six-stage regression scale; 56% of all patients responded well to ...