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  1. Article

    Conclusions from the cooperative osteosarcoma (OS) studies COSS-80 and COSS-82 for future therapeutic strategies

    K. Winkler, G. Beron, C. Purfürst, J. Berger in Journal of Cancer Research and Clinical On… (1986)

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    Article

    Adjuvant chemotherapy in osteosarcoma — Effects of cisplatinum, BCD, and fibroblast interferon in sequential combination with HD-MTX and adriamycin

    In a cooperative adjuvant chemotherapy study of osteosarcoma (COSS-80), 192 patients were registered from December 1979 to March 1982. Fortyone patients have been excluded from study because of their nonadjuva...

    K. Winkler, G. Beron, R. Kotz in Journal of Cancer Research and Clinical On… (1983)

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    Article

    Toxicity associated with combination chemotherapy for osteosarcoma: A report of the cooperative osteosarcoma study (COSS 80)

    The treatment-associated toxicity in 189 patients entered in the COSS-80 Study was analyzed. The sequential use of high-dose methotrexate (HDMTX) with citrovorum factor rescue (CFR) andcis-platinum may be additiv...

    H. Jürgens, G. Beron, K. Winkler in Journal of Cancer Research and Clinical Oncology (1983)

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    Article

    Morphological grades of regression in osteosarcoma after polychemotherapy — Study COSS 80

    The histologic grade of regression of 50 osteosarcomas after polychemotherapy — according to the protocol study, COSS 80 — was classified on a six-stage regression scale; 56% of all patients responded well to ...

    M. Salzer-Kuntschik, G. Delling, G. Beron in Journal of Cancer Research and Clinical On… (1983)