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Article
Open AccessImpact of Escherichia coli K12 and O18:K1 on human platelets: Differential effects on platelet activation, RNAs and proteins
Blood platelets can interact with bacteria, possibly leading to platelet activation, cytokine and microparticle release and immune signalling. Besides, bacteria can also affect the platelet RNA content. We inv...
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Article
Open AccessNext-generation sequencing identifies major DNA methylation changes during progression of Ph+ chronic myeloid leukemia
Little is known about the impact of DNA methylation on the evolution/progression of Ph+ chronic myeloid leukemia (CML). We investigated the methylome of CML patients in chronic phase (CP-CML), accelerated phas...
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Article
Maternal interleukin-6 (−174) C/C polymorphism is associated with chorioamnionitis and cystic periventricular leucomalacia of the preterm infant
To evaluate the association between maternal interleukin (IL)-6 G(−174)C polymorphism and cystic periventricular leukomalacia (cPVL) of the preterm newborn.
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Article
High expression of lipoprotein lipase in poor risk B-cell chronic lymphocytic leukemia
We investigated the pattern of lipoprotein lipase (LPL) expression in B-cell chronic lymphocytic leukemia (B-CLL) and assessed its prognostic relevance. Expression of LPL mRNA as well as protein was highly res...
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Article
Prognostic significance of molecular staging by PCR-amplification of immunoglobulin gene rearrangements in diffuse large B-cell lymphoma (DLBCL)
The prognostic value of the detection of peripheral blood (PB) and/or bone marrow (BM) involvement by polymerase chain reaction (PCR) amplification of rearranged immunoglobulin heavy chain (IgH) and immunoglob...
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Article
High expression of activation-induced cytidine deaminase (AID) mRNA is associated with unmutated IGVH gene status and unfavourable cytogenetic aberrations in patients with chronic lymphocytic leukaemia
Activation-induced cytidine deaminase (AID) is essential for somatic hypermutation of B-cells. We investigated the expression of AID mRNA by real-time polymerase chain reaction (PCR) in peripheral blood mononu...
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Chapter and Conference Paper
4G/5G Promoter Polymorphism In The Plasminogen Activator lnhibitor-1 Gene In Children With Systemic Meningococcaemia
Fulminant meningococcaemia is a life-threatening disease with septic shock, disseminated intravascular coagulation (DIC), and hemorrhagic skin necrosis, and is associated with a high morbidity and mortality (1). ...
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Chapter and Conference Paper
Deep Venous Thrombosis of the Lower Extremity in a 16-Year-Old Girl with Homozygous MTHFR- and Heterozygous Factor V Leiden-Mutation
Although relatively rare,thromboembolic complications do occur in pediatric patients [1] and cause significant morbidity with occasional mortality.Venous thrombosis is a multicausal disease involving acquired and...
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Article
Diffuse large B-cell lymphomas with plasmablastic/plasmacytoid features are associated with TP53 deletions and poor clinical outcome
To define reproducible criteria for subgroups of diffuse large B-cell lymphomas (DLBCL), including lymphomas with plasmablastic/plasmacytoid features (PB/PC-Fs), we investigated 66 DLBCL; the samples were cate...
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Article
Treatment of HBV-carrying lymphoma patients with Rituximab and CHOP: a diagnostic and therapeutic challenge
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Article
Alternative end-joining in follicular lymphomas’ t(14;18) translocation
T(14;18) chromosomal translocation is assumed to result from illegitimate rearrangement between the BCL2 proto-oncogene and the IGH locus during the DH to JH joining phase of V(D)J recombination in early B cells....
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Article
Long-term clinical and molecular remission after allogeneic stem cell transplantation (SCT) in patients with poor prognosis non-Hodgkin's lymphoma
From 1987 to 1999 35 patients with poor prognosis non-Hodgkin's lymphoma (NHL) underwent allogeneic stem cell transplantation (SCT) at the University Hospitals of Vienna and Graz. Initial biopsy specimens were...
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Article
Treatment of leukemic relapse after allogeneic stem cell transplantation with cytotoreductive chemotherapy and/or immunotherapy or second transplants
We analyzed toxicity and efficacy of chemotherapy (CT) or second stem cell transplantation (SCT) and/or immunotherapy defined as stop of immunosuppression (IS) or donor leukocyte infusion (DLI) in 47 patients ...
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Article
Evaluation of a highly specific functional test for the detection of factor V Leiden
In the present study, a new functional test for the detection of increased resistance of coagulation factor V to degradation by activated protein C (factor V Leiden mutation) was evaluated. The STA-STACLOT APC...
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Article
Excellent disease eradication by myeloablative therapy and stem-cell transplantation in patients with acute myelogenous leukemia
Between February 1982 and 1999, 118 consecutive patients (65 male, 53 female) with acute myelogenous leukemia (AML), with a median age of 35 years (range 17–56 years), received stem-cell grafts from a human l...
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Chapter and Conference Paper
Resistenz gegen aktiviertes Protein C, Faktor-V-Leiden und Prothrombin-G-20210-A-Variante bei Kindern mit ischämischen Schlaganfällen
Zerebrale Infarkte werden im Kindesalter mit einer Inzidenz von 1,2 Fällen/100.000 Kindern pro Jahr beobachtet [4]. Obwohl mehr als 70 verschiedene Ursachen oder potentielle Risikofaktoren für die Entwicklung ...
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Article
Long-term follow-up of patients after related- and unrelated-donor bone marrow transplantation for chronic myelogenous leukemia
Between January 1983 and December 1997, 88 patients (36 female, 52 male, median age 37 years, range 19–57) with chronic myelogenous leukemia (CML) underwent allogeneic bone marrow transplantation (BMT) at the...
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Article
Monitoring of minimal residual leukemia in patients with MLL-AF9 positive acute myeloid leukemia by RT-PCR
Twenty-seven patients with AML and MLL gene rearrangement were analyzed by a reverse transcriptase polymerase chain reaction (RT-PCR) for the MLL-AF9 translocation. The MLL-AF9 fusion transcript was detected in s...
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Article
Hematopoietic donor chimerism and graft-versus-myeloma effect in relapse of multiple myeloma after allogeneic bone marrow transplantation
A large group of patients relapsing after allogeneic bone marrow transplantation (BMT) have obtained remission after infusion of leukocytes from their original donor, suggesting a graft-versus-myeloma effect....
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Article
Genetic fingerprinting in mouthwashes of patients after allogeneic bone marrow transplantation
Detection of chimerism by PCR analysis of short tandem repeats (STR) in blood samples of patients who received allogeneic bone marrow transplantation (BMT) has proved to be an important method for early detect...