7 Result(s)

Article

Prolonged glucose infusion into conscious rats inhibits early steps in insulin signalling and induces translocation of GLUT4 and protein kinase C in skeletal muscle

Previous studies on diabetic patients have shown that hyperglycaemia increases glucose uptake in an apparently insulin-independent manner. However, the molecular mechanism has not been clarified.

B. Houdali, V. Nguyen, H. P. T. Ammon, M. Haap, W. Schechinger, F. Machicao… in Diabetologia (2002)

Article

The tumour necrosis factor alpha –238 G → A and –308 G → A promoter polymorphisms are not associated with insulin sensitivity and insulin secretion in young healthy relatives of Type II Diabetic patients

Aims/hypothesis. Tumour necrosis factor-α (TNF-α) is believed to influence skeletal muscle insulin resistance. Two G → A transitions in the promoter region of TNF- α at position –...

M. Koch, K. Rett, A. Volk, E. Maerker, K. Haist, M. Weisser, A. Rettig… in Diabetologia (2000)

Article

Lipolysis in skeletal muscle is rapidly regulated by low physiological doses of insulin

Aims/hypothesis. Both patients with Type II (non-insulin-dependent) diabetes mellitus and normoglycaemic, insulin resistant subjects were shown to have an increased lipid content in skeletal musc...

S. Jacob, B. Hauer, R. Becker, S. Artzner, P. Grauer, K. Löblein… in Diabetologia (1999)

Article

35th Annual Meeting of the European Association for the Study of Diabetes

A. Melander, J. Olsson, G. Lindberg, A. Salzman, T. Howard, P. Stang… in Diabetologia (1999)

Article

The PPARγ2 amino acid polymorphism Pro 12 Ala is prevalent in offspring of Type II diabetic patients and is associated to increased insulin sensitivity in a subgroup of obese subjects

Aims/hypothesis. Recently a mutation in the coding sequence of the adipocyte specific isoform peroxisome proliferator-activated receptor γ2 (PPARγ2) was described, leading to the substitution of ...

M. Koch, K. Rett, E. Maerker, A. Volk, K. Haist, M. Deninger, W. Renn… in Diabetologia (1999)

Article

Insulin-induced translocation of GLUT 4 in skeletal muscle of insulin-resistant Zucker rats

The genetically obese Zucker rat (fa/fa) is an animal model with severe insulin resistance of the skeletal muscle. We investigated whether a defect of insulin-dependent glucose transporter (GLUT 4) translocati...

P. Galante, E. Maerker, R. Scholz, K. Rett, L. Herberg, L. Mosthaf… in Diabetologia (1994)

Article

Normal insulin receptor tyrosine kinase activity and glucose transporter (GLUT 4) levels in the skeletal muscle of hyperinsulinaemic hypertensive rats

The spontaneous hypertensive rat is an animal model characterized by a syndrome of hypertension, insulin resistance and hyperinsulinaemia. To elucidate whether in analogy to other insulin resistant animal mode...

S. Bader, R. Scholz, M. Kellerer, S. Tippmer, K. Rett, S. Mathaei… in Diabetologia (1992)