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Chapter
Which Margin Should Be Added to the GTV?
During the past decennium, precision of radiotherapy treatment has increased with the implementation of highly-conformal radiotherapy techniques. The steep dose gradients of intensity-modulated radiotherapy (I...
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Chapter
When Should IGRT Be Done?
The therapeutic window of radiotherapy is defined by the balance between the tumor control probability (TCP) and the normal tissue complication probability (NTCP). The tremendous evolution from bony-landmark t...
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Living Reference Work Entry In depth
Radiation Therapy in Esophageal/Gastroesophageal Cancer
Esophageal cancer is a highly aggressive disease, characterized by a rapid lymphatic and hematological spread, resulting in a 5-year overall survival from 15% to 25%. Although the incidence of squamous cell ca...
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Article
The survival impact of neoadjuvant hormonal therapy before radical prostatectomy for treatment of high-risk prostate cancer
Several randomized controlled trials assessed the outcomes of patients treated with neoadjuvant hormonal therapy (NHT) before radical prostatectomy (RP). The majority of them included mainly low and intermedia...
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Article
Comparison of diagnostic accuracy of 111In-pentetreotide SPECT and 68Ga-DOTATOC PET/CT: A lesion-by-lesion analysis in patients with metastatic neuroendocrine tumours
To compare the diagnostic accuracy of 111In-pentetreotide-scintigraphy with 68Ga-DOTATOC-positron emission tomography (PET)/computed tomography (CT) in patients with metastatic-neuroendocrine tumour (NET) schedul...
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Article
Open AccessCombining bevacizumab and chemoradiation in rectal cancer. Translational results of the AXEBeam trial
This study characterises molecular effect of bevacizumab, and explores the relation of molecular and genetic markers with response to bevacizumab combined with chemoradiotherapy (CRT).
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Article
Does 11C-choline PET-CT contribute to multiparametric MRI for prostate cancer localisation?
The aim of this work was to determine whether 11C-choline positron emission tomography (PET)–computed tomography (CT) makes a positive contribution to multiparametric magnetic resonance imaging (MRI) for localisa...
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Article
Open AccessEvaluation of hypoxia in an experimental rat tumour model by [18F]Fluoromisonidazole PET and immunohistochemistry
This study aimed to evaluate tumour hypoxia by comparing [18F]Fluoromisonidazole uptake measured using positron emission tomography ([18F]FMISO-PET) with immunohistochemical (IHC) staining techniques. Syngeneic r...
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Article
Open AccessUse of thymidine analogues to indicate vascular perfusion in tumours
Temporary reduction in blood-flow within tumour blood vessels can reduce oxygen supply leading to transient perfusion-limited hypoxia. Consequent selection of cells with mutations and reduced radiosensitivity ...
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Chapter and Conference Paper
Cytokeratin 14, 18, and 19 Expression in Normal Epithelium and in Squamous Cancer of the Esophagus
The normal esophagus is lined by a tough non-keratinizing stratified squamous epithelium, except for a short segment of columnar epithelium at the gastroesophageal junction. Different cell layers have classica...
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Chapter and Conference Paper
Cell Kinetics and Epidermal Growth Factor Receptor Expression: Useful Guides in Esophageal Cancer?
Radiotherapy and chemotherapy both cause cell death in tumors as well as in normal tissues. As soon as a certain level of damage is reached in the tissue, repopulation starts via feedback mechanisms. In fast p...
