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Article
Open AccessCisplatin-DNA adduct formation in patients treated with cisplatin-based chemoradiation: lack of correlation between normal tissues and primary tumor
In this study, the formation of cisplatin-DNA adducts after concurrent cisplatin-radiation and the relationship between adduct-formation in primary tumor tissue and normal tissue were investigated.
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Article
Open AccessAccelerated hyperfractionation (AHF) compared to conventional fractionation (CF) in the postoperative radiotherapy of locally advanced head and neck cancer: influence of proliferation
Based on the assumption that an accelerated proliferation process prevails in tumour cell residues after surgery, the possibility that treatment acceleration would offer a therapeutic advantage in postoperativ...
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Article
Open AccessUse of thymidine analogues to indicate vascular perfusion in tumours
Temporary reduction in blood-flow within tumour blood vessels can reduce oxygen supply leading to transient perfusion-limited hypoxia. Consequent selection of cells with mutations and reduced radiosensitivity ...
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Chapter and Conference Paper
Present Status of EORTC Trials of Hyperfractionated and Accelerated Radiotherapy on Head and Neck Carcinoma
The European Organization for Research on Treatment of Cancer (EORTC) Cooperative Group of Radiotherapy started phase II and III trials on modified fractionation schemes in 1980. As of June 1, 1992, 2006 patie...
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Chapter
Radiobiology Studies at Petten: Status on Cell Culture, Mice and Dog Experiments
Boron neutron capture therapy (BNCT) with epithermal neutrons (1 eV to 10 keV) will achieve the necessary deep penetration for treating brain tumours. Epithermal neutrons will be moderated by the tissue mass b...
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Chapter
Boron Concentration Measurements for the Petten BNCT Project
In Petten two lines of BNCT research are conducted, one aiming at the development and construction of a clinical facility at the High Flux Reactor (1–3), and the other one studying the fundamental aspects of B...
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Chapter
Comparative Pharmacokinetics and Distribution Studies of Boric Acid, L-BPA and BSH in Two Murine Tumour Models
One of the requirements of Boron Neutron Capture Therapy (BNCT) is that the boronated compounds be selectively incorporated and retained in the tumour cells while remaining at a low level in irradiated normal ...
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Article
Antibodies against cisplatin-modified DNA and cisplatin-modified (di) nucleotides
Cytotoxic effects ofcis-diamminedichloroplatinum-(II) (cis-DDP) are thought to be mediated by binding to DNA. Studies on binding ofcis-DDP to cellular DNA rely heavily on the availability of specific antibodies. ...
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Article
Polymer-coated albumin microspheres as carriers for intravascular tumour targeting of cisplatin
We used a poly-lactide-co-glycolide polymer (PLAGA 50: 50) to formulate cisplatin (cDDP) into microspheres designed for intravascular administration. Two systems were developed, PLAGA-coated albumin microspher...
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Article
A new intraperitoneal tumor model in the rat
A new tumour model that is particularly suitable for testing intraperitoneal chemotherapy is described. Single tumours were induced to grow in the mesentery of rats by the implantation of small pieces taken fr...
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Chapter
Visualization of Cisplatin-DNA and Carboplatin-DNA Adducts in Tissues and Cultured Cells
We are interested in the contribution of cisplatin- (cis-diamminedichloroplatinum, cDDP) and carboplatin- (cis-diammine (1,1-cyclobutanedicarboxylato)-platinum(II), CBDCA) induced DNA modifications to the cyto...
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Chapter
Cisplatin-Radiation Interactions in Tumours and Normal Tissues
Studies were undertaken to define the relative importance of mechanisms by which cisplatin can enhance the effects of radiation treatments. In a mouse tumour and in three different normal tissues, the magnitud...
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Chapter and Conference Paper
Combined Treatment with Radiation and Anti-Cancer Drugs: Experimental and Clinical Results
The combination of radiotherapy and chemotherapy for the treatment of patients with malignant tumours has found increasing use during the last decade. The main aims of this combined treatment approach are to i...
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Article
A bioassay for cyclophosphamide in blood, lung and tumour
A bioassay has been developed to detect and quantify the concentration of cytotoxic metabolites of cyclophosphamide (CY) in blood, tumour, and lungs of mice. Extracts were made of blood or solid tissues taken ...
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Chapter
Comparison of Natural and Artificial Lung Metastases from a Murine Tumour of Spontaneous Origin
The metastatic potential of the non-immunogenic CBA SA F tumour was investigated. Eradication of subcutaneous tumours of different sizes with 80Gy of X-rays resulted in lung metastases incidence increasing fro...
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Article
The Incidence of Lung Metastases in C3h Mice after Treatment of Implanted Solid Tumours with X-rays or Surgery
C3H mice were implanted with pieces of spontaneous mammary carcinoma which were irradiated or removed surgically when they had grown to 6·5 mm mean diameter. The incidence of lung metastases was determined fro...
