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Article
Open AccessSimulating multiple variability in spatially resolved transcriptomics with scCube
A pressing challenge in spatially resolved transcriptomics (SRT) is to benchmark the computational methods. A widely-used approach involves utilizing simulated data. However, biases exist in terms of the curre...
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Article
Underwater Non-stationary Acoustic Signal Detection Based on the STHOC Noise Suppression
Underwater non-stationary acoustic signal detection has a variety of applied research in marine, military and civilian fields. Moreover, the signal has strong randomness and short-term characteristics. Usually...
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Article
Open AccessSalvianolic acid C attenuates cerebral ischemic injury through inhibiting neuroinflammation via the TLR4-TREM1-NF-κB pathway
Stroke is a leading cause of mortality and disability with ischemic stroke being the most common type of stroke. Salvianolic acid C (SalC), a polyphenolic compound found in Salviae Miltiorrhizae Radix et Rhizoma,...
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Article
Open AccessSingle-cell transcriptomic analysis reveals tumor cell heterogeneity and immune microenvironment features of pituitary neuroendocrine tumors
Pituitary neuroendocrine tumors (PitNETs) are one of the most common types of intracranial tumors. Currently, the cellular characteristics of normal pituitary and various other types of PitNETs are still not c...
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Chapter and Conference Paper
A Novel Crossover Operator Based on Grey Wolf Optimizer Applied to Feature Selection Problem
Alzheimer’s disease (AD) poses challenges in feature selection due to the limited number of features relative to the large number of samples. To address this issue, we propose a novel crossover operator called...
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Article
Open AccessHypovirulence-associated mycovirus epidemics cause pathogenicity degeneration of Beauveria bassiana in the field
The entomogenous fungus Beauveria bassiana is used as a biological insecticide worldwide, wild B. bassiana strains with high pathogenicity in the field play an important role in controlling insect pests via not o...
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Article
Digital Circuit for Fast Scan Voltammetry Based on Dual-Frequency Method
In this work, a digital circuit for fast scan voltammetry (FSV) was developed based on dual-frequency method. It consists of six main modules including the microcontroller unit, signal generator module, soluti...
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Article
Open AccessReconstruction of the cell pseudo-space from single-cell RNA sequencing data with scSpace
Tissues are highly complicated with spatial heterogeneity in gene expression. However, the cutting-edge single-cell RNA-seq technology eliminates the spatial information of individual cells, which contributes ...
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Chapter
Explaining Deep Learning Based Security Applications
Many research attempts have been made to develop explanation techniques to provide interpretable explanations for deep learning results. However, the produced methods are optimized for non-security tasks (e.g., i...
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Article
Open AccessBrain tumour segmentation based on an improved U-Net
Automatic segmentation of brain tumours using deep learning algorithms is currently one of the research hotspots in the medical image segmentation field. An improved U-Net network is proposed to segment brain ...
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Article
Open AccessCarboplatin and nab-paclitaxel chemotherapy with or without atezolizumab as front-line management for treatment-naïve metastatic nonsquamous non-small cell lung cancer with PD-L1 staining: a retrospective study
The aim of this retrospective review was to compare the efficacy and safety of the atezolizumab plus carboplatin and nab-paclitaxel regimen versus the carboplatin and nab-paclitaxel regimen as front-line manag...
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Article
Electrochemical aptasensor for Staphylococcus aureus by stepwise signal amplification
An electrochemical aptasensor for ultrasensitive detection of Staphylococcus aureus (SA) has been developed based on stepwise signal amplification. In the sample processing stage, the specific recognition between...
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Article
Open AccessLenvatinib plus TACE with or without pembrolizumab for the treatment of initially unresectable hepatocellular carcinoma harbouring PD-L1 expression: a retrospective study
The aim of this retrospective study was to compare the clinical outcomes of pembrolizumab-lenvatinib-transarterial chemoembolization (TACE) versus lenvatinib-TACE sequential therapy in selected populations of ...
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Article
Open AccessThree-dimensional shape and deformation measurement on complex structure parts
Stereo digital image correlation technique (stereo-DIC or 3D-DIC) has been widely used in three-dimensional (3D) shape and deformation measurement due to its high accuracy and flexibility. But it is a tough ta...
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Article
Elucidating minimal residual disease of paediatric B-cell acute lymphoblastic leukaemia by single-cell analysis
Minimal residual disease that persists after chemotherapy is the most valuable prognostic marker for haematological malignancies and solid cancers. Unfortunately, our understanding of the resistance elicited i...
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Chapter and Conference Paper
No Pie in the Sky: The Digital Currency Fraud Website Detection
In recent years, digital currencies based on blockchain technology are growing rapidly. Therefore, many criminal cases related to digital currency also took place. One of the most common ways is to induce vict...
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Article
Open AccessPembrolizumab plus lenvatinib with or without hepatic arterial infusion chemotherapy in selected populations of patients with treatment-naive unresectable hepatocellular carcinoma exhibiting PD-L1 staining: a multicenter retrospective study
Not all patients with unresectable hepatocellular carcinoma (uHCC) benefit from treatment with immune checkpoint inhibitors and molecular-targeted agents. The aim of this retrospective study was to assess the ...
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Article
Self-interference cancellation for cooperative jamming communications with nonideal alignment and channel equalization
For the security of wireless communications, cooperative jamming can be used to intentionally degrade the signal-to-noise ratios received by eavesdroppers. Unfortunately, this jamming may also propagate to the...
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Article
Effects of Fast Shot Speed and Wall Thickness on the Microstructures and Mechanical Properties of the High Pressure Die-casting 6061-SiC Composites
In this work, a 6061-SiC composite was prepared using the compound casting method and then processed using a vacuum-assisted high-pressure die-casting technology under fast shot speeds of 1, 2 and 3 m/s, respe...
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Article
Open AccessDeterminants of pain in advanced HCC patients recieving hepatic artery infusion chemotherapy
Purpose Hepatic arterial infusion chemotherapy (HAIC) is one of the options to treat unresectable hepatocellular carcinoma (HCC). The majority of HCC patients suffer great pain in the course of HAIC treatment. To...
