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Article
Enhancing the multi-encoder-based cutting force estimation along the stationary axis of a machine tool with multiple inertia dynamics
Wideband cutting force sensing is a key technology for process monitoring. Sensorless cutting force estimation using the internal servo information of a machine tool with ball-screw-driven stages has been stud...
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Article
Open AccessNovel exterior cover design for radiant heat resistance of firefighting robots in large-scale petrochemical complex fires
Fires in petrochemical complexes are inaccessible because of the intense radiant heat from flames. Therefore, water cannon robots require radiant heat countermeasures to perform firefighting safely. Convention...
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Chapter
Clinical Application of iPSC-Derived Cardiomyocytes in Patients with Advanced Heart Failure
Restoration of damaged cardiac tissues via supplementation with functional cardiomyocytes is an ideal medical treatment for advanced heart failure. Because human induced pluripotent stem cells (hiPSCs) can the...
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Article
Open AccessRelationship between fatty liver change and nutritional status after total gastrectomy in gastric cancer patients: a retrospective study
The relationship between chronological nutritional changes and development of fatty liver after total gastrectomy (TG) in gastric cancer (GC) patients is still unclear. This study aimed to evaluate relationshi...
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Article
Open AccessAdvanced gastric cancer with abdominal wall invasion treated with curative resection after chemotherapy: a case report
In patients with gastric cancer, 6–27% of patients are diagnosed with T4b disease that invades adjacent organs, and curative resection can improve the prognosis of these patients.
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Article
Open AccessMetabolism of human pluripotent stem cells and differentiated cells for regenerative therapy: a focus on cardiomyocytes
Pluripotent stem cells (PSCs) exhibit promising application in regenerative therapy, drug discovery, and disease modeling. While several protocols for differentiating somatic cells from PSCs exist, their use i...
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Protocol
A Method for Cardiac Differentiation, Purification, and Cardiac Spheroid Production of Human Induced Pluripotent Stem Cells
Human induced pluripotent stem cells (hiPSCs) are one of the most promising cell sources for regenerative medicine. To realize the promise of hiPSCs for cardiac regenerative therapy, three major obstacles must...
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Article
Open AccessToward the realization of cardiac regenerative medicine using pluripotent stem cells
Heart transplantation (HT) is the only radical treatment available for patients with end-stage heart failure that is refractory to optimal medical treatment and device therapies. However, HT as a therapeutic o...
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Article
Open AccessGastric adenocarcinoma of fundic gland type arising from heterotopic gastric glands during a 19-year follow-up period
A 73-year-old man with prior history of duodenal ulcer has been undergoing periodic upper gastrointestinal endoscopy since 1999. In 2017, a 25-mm submucosal tumor-like protrusion was detected in the lesser cur...
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Article
Open AccessAn effective detachment system for human induced pluripotent stem cells cultured on multilayered cultivation substrates using resonance vibrations
Clinical application of human induced pluripotent stem cells (hiPSCs) has been hampered by the lack of a practical, scalable culture system. Stacked culture plates (SCPs) have recently attracted attention. How...
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Article
Open AccessThe neutrophil/lymphocyte ratio as a predictor of peritoneal metastasis during staging laparoscopy for advanced gastric cancer: a retrospective cohort analysis
The use of staging laparoscopy (SL) has become widespread in patients with advanced gastric cancer (GC). This study aimed to evaluate the predictive value of the neutrophil/lymphocyte ratio (NLR) for the prese...
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Chapter
The Oncoprotein Gankyrin/PSMD10 as a Target of Cancer Therapy
Gankyrin (also called PSMD10, p28, or p28GANK) is a crucial oncoprotein that is upregulated in various cancers and assumed to play pivotal roles in the initiation and progression of tumors. Although the in vitro ...
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Article
Open AccessCorrection to: Consistent map building in petrochemical complexes for firefighter robots using SLAM based on GPS and LIDAR
Following publication of the original article [1], the authors reported that one of the authors’ name is spelled incorrectly. In this Correction the incorrect and correct author name are shown. The original pu...
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Article
Open AccessConsistent map building in petrochemical complexes for firefighter robots using SLAM based on GPS and LIDAR
The objective of this study was to achieve simultaneous localization and map** (SLAM) of firefighter robots for petrochemical complexes. Consistency of the SLAM map is important because human operators compa...
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Article
Open AccessTRPV4-dependent induction of a novel mammalian cold-inducible protein SRSF5 as well as CIRP and RBM3
Cold-inducible RNA-binding protein (CIRP) and RNA-binding motif protein 3 (RBM3) are two evolutionarily conserved RNA-binding proteins that are structurally related to hnRNPs and upregulated in response to mod...
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Article
Open AccessManipulation of Pluripotent Stem Cell Metabolism for Clinical Application
Pluripotent stem cells (PSCs) have the capacity to differentiate into various types of cells, and are promising cell sources for regenerative therapy and drug screening. However, to realize the clinical applic...
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Article
Open AccessCryoinjury-induced acute myocardial infarction model and ameroid constrictor-induced ischemic heart disease model in adult micro-mini pigs for preclinical studies
Coronary artery diseases (CAD) are the most commonly occurring disorders in the developed countries. Development of new therapeutics and their success in clinical studies require confirmation of therapeutic ef...
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Reference Work Entry In depth
Gankyrin
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Chapter
Road to Heart Regeneration with Induced Pluripotent Stem Cells
Restoration of cardiac function is the most desirable treatment of severe heart failure. However, effective regenerative therapy for the lost cardiomyocytes is currently an unmet medical need. Induced pluripot...
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Article
Open AccessDual phosphodiesterase type 5 inhibitor therapy for refractory pulmonary arterial hypertension: a pilot study
Recent vasodilating drugs have improved prognosis of Pulmonary arterial hypertension (PAH). Some reports describe the merits of combination therapies for PAH, and this study evaluated the efficacy and safety o...
