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Article
Open AccessStart codon variant in LAG3 is associated with decreased LAG-3 expression and increased risk of autoimmune thyroid disease
Autoimmune thyroid disease (AITD) is a common autoimmune disease. In a GWAS meta-analysis of 110,945 cases and 1,084,290 controls, 290 sequence variants at 225 loci are associated with AITD. Of these variants,...
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Article
Open AccessMolecular benchmarks of a SARS-CoV-2 epidemic
A pressing concern in the SARS-CoV-2 epidemic and other viral outbreaks, is the extent to which the containment measures are halting the viral spread. A straightforward way to assess this is to tally the activ...
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Chapter and Conference Paper
Defining Gestural Interactions for Large Vertical Touch Displays
As new technologies emerge, so do new ways of interacting with the digital domain. In this paper, the touch interaction paradigm is challenged for use on large touch displays of 65 in. in size. We present a ge...
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Article
Regulatory mutations in TBX3 disrupt asymmetric hair pigmentation that underlies Dun camouflage color in horses
Leif Andersson, Gregory Barsh and colleagues show that Dun camouflage color in horses is due to TBX3 expression in hair follicles, which causes asymmetric distribution of hair follicle melanocytes and reduced ...
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Article
Evolution of Darwin’s finches and their beaks revealed by genome sequencing
Darwin’s finches, inhabiting the Galápagos archipelago and Cocos Island, constitute an iconic model for studies of speciation and adaptive evolution. Here we report the results of whole-genome re-sequencing of...
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Article
Open AccessAnalysis of structural diversity in wolf-like canids reveals post-domestication variants
Although a variety of genetic changes have been implicated in causing phenotypic differences among dogs, the role of copy number variants (CNVs) and their impact on phenotypic variation is still poorly underst...
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Article
Open AccessGenome-wide copy number variant discovery in dogs using the CanineHD genoty** array
Substantial contribution to phenotypic diversity is accounted for by copy number variants (CNV). In human, as well as other species, the effect of CNVs range from benign to directly disease-causing which motiv...
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Article
Open AccessNovel origins of copy number variation in the dog genome
Copy number variants (CNVs) account for substantial variation between genomes and are a major source of normal and pathogenic phenotypic differences. The dog is an ideal model to investigate mutational mechani...
