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Article
Open AccessLinked genetic variants on chromosome 10 control ear morphology and body mass among dog breeds
The domestic dog is a rich resource for map** the genetic components of phenotypic variation due to its unique population history involving strong artificial selection. Genome-wide association studies have r...
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Article
Open AccessCandidate genes and functional noncoding variants identified in a canine model of obsessive-compulsive disorder
Obsessive-compulsive disorder (OCD), a severe mental disease manifested in time-consuming repetition of behaviors, affects 1 to 3% of the human population. While highly heritable, complex genetics has hampered...
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Article
Open AccessGenome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B
Canine osteosarcoma is clinically nearly identical to the human disease, but is common and highly heritable, making genetic dissection feasible.
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Article
The genomic signature of dog domestication reveals adaptation to a starch-rich diet
Whole-genome resequencing of dogs and wolves helps identify genomic regions that are likely to represent targets for selection during dog domestication.
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Open AccessNovel origins of copy number variation in the dog genome
Copy number variants (CNVs) account for substantial variation between genomes and are a major source of normal and pathogenic phenotypic differences. The dog is an ideal model to investigate mutational mechani...
