5 Result(s)
within
Johan L. Gabrielsson
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Article
An extended physiological pharmacokinetic model of methadone disposition in the rat: Validation and sensitivity analysis
An extended physiological model of methadone disposition in the rat was constructed and evaluated in various tests of model validity. A separate circulation model of the fetus was included due to the large tis.....
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Article
Analysis of pethidine disposition in the pregnant rat by means of a physiological flow model
The disposition of pethidine (meperidine) in the pregnant rat is described by means of a physiological flow model. The model includes arterial and venous blood, brain, fat, fetal, hepatic, intestinal, muscular.....
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Article
Analysis of methadone disposition in the pregnant rat by means of a physiological flow model
A physiological flow model simulating the pregnant rat is constructed for methadone. The model includes brain, fetal, hepatic, intestinal, muscular, pulmonar, and renal tissues. Since methadone kinetics may pr...
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Article
A physiologically based pharmacokinetic model for theophylline disposition in the pregnant and nonpregnant rat
There are numerous studies which examine the disposition of theophylline from a traditional point of view. Information about the behaviour of drugs, including theophylline, is, however, very scarce when invest.....
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Article
A physiological pharmacokinetic model for morphine disposition in the pregnant rat
A physiological model was used to examine the disposition of morphine in the pregnant rat. In the model was incorporated an expression of both a linear and a nonlinear binding term of morphine to the maternal .....
