10 Result(s)

Article

Author Correction: Genome-wide association study identifies Sjögren’s risk loci with functional implications in immune and glandular cells

Bhuwan Khatri, Kandice L. Tessneer, Astrid Rasmussen… in Nature Communications (2023)

Article

Author Correction: Genome-wide association study identifies Sjögren’s risk loci with functional implications in immune and glandular cells

Bhuwan Khatri, Kandice L. Tessneer, Astrid Rasmussen… in Nature Communications (2022)

Article

Genome-wide association study identifies Sjögren’s risk loci with functional implications in immune and glandular cells

Sjögren’s disease is a complex autoimmune disease with twelve established susceptibility loci. This genome-wide association study (GWAS) identifies ten novel genome-wide significant (GWS) regions in Sjögren’s ...

Bhuwan Khatri, Kandice L. Tessneer, Astrid Rasmussen… in Nature Communications (2022)

Article

Impaired activation of STAT5 upon IL-2 stimulation in Tregs and elevated sIL-2R in Sjögren’s syndrome

Interleukin-2 (IL-2) and the high-affinity IL-2 receptor (IL-2R) are essential for the survival of regulatory T cells (Tregs) which are the main players in immune tolerance and prevention of autoimmune disease...

Magdalena Keindl, Richard Davies, Brith Bergum… in Arthritis Research & Therapy (2022)

Article

Lipid, fatty acid, carnitine- and choline derivative profiles in rheumatoid arthritis outpatients with different degrees of periodontal inflammation

Rheumatoid arthritis (RA) and periodontitis are chronic inflammatory diseases with several pathogenic pathways in common. Evidence supports an association between the diseases, but the exact underlying mechani...

Kathrin Beyer, Stein Atle Lie, Bodil Bjørndal, Rolf K. Berge… in Scientific Reports (2021)

Article

Long-term follow-up in primary Sjögren’s syndrome reveals differences in clinical presentation between female and male patients

Despite men being less prone to develop autoimmune diseases, male sex has been associated with a more severe disease course in several systemic autoimmune diseases. In the present study, we aimed to investigat...

Jorge I. Ramírez Sepúlveda, Marika Kvarnström, Per Eriksson… in Biology of Sex Differences (2017)

Article

The neutrophil protein S100A12 is associated with a comprehensive ultrasonographic synovitis score in a longitudinal study of patients with rheumatoid arthritis treated with adalimumab

The calcium-binding protein S100A12 correlates with measures of disease activity in patients with rheumatoid arthritis (RA). The protein reflects neutrophil activation and the present objective was to explore ...

Hilde Haugedal Nordal, Johan G Brun, Anne-Kristine Halse… in BMC Musculoskeletal Disorders (2014)

Article

Altered phenotype and Stat1 expression in Toll-like receptor 7/8 stimulated monocyte-derived dendritic cells from patients with primary Sjögren’s syndrome

Dendritic cells (DC) are the most potent antigen-presenting cells of the immune system, involved in both initiating immune responses and maintaining tolerance. Dysfunctional and via toll-like receptor (TLR) li...

Petra Vogelsang, Marie Karlsen, Johan G Brun… in Arthritis Research & Therapy (2014)

Article

In vitro suppression of immune responses using monocyte-derived tolerogenic dendritic cells from patients with primary Sjögren's syndrome

Therapeutic vaccination with antigen-specific tolerogenic dendritic cells (tolDC) might become a future option of individualized therapy for patients with autoimmune diseases. In this study, we tested the poss...

Roman Volchenkov, Johan G Brun, Roland Jonsson, Silke Appel in Arthritis Research & Therapy (2013)

Article

Short-term duodenal seal oil administration normalised n-6 to n-3 fatty acid ratio in rectal mucosa and ameliorated bodily pain in patients with inflammatory bowel disease

A high dietary intake of n-6 compared to n-3 fatty acids (FAs) may promote the production of pro-inflammatory eicosanoids and cytokines. In two recent studies, short-term (10-day) duodenal administration of n-...

Tormod Bjørkkjær, Johan G Brun, Merete Valen, Gülen Arslan… in Lipids in Health and Disease (2006)