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  1. Article

    Open Access

    N6-methyladenosine demethylase FTO regulates synaptic and cognitive impairment by destabilizing PTEN mRNA in hypoxic-ischemic neonatal rats

    Hypoxic-ischemic brain damage (HIBD) can result in significant global rates of neonatal death or permanent neurological disability. N6-methyladenosine (m6A) modification of RNA influences fundamental aspects o...

    Jianhui Deng, Yanling Liao, Jianghu Chen, Andi Chen, Shuyan Wu… in Cell Death & Disease (2023)

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  2. No Access

    Article

    Dexmedetomidine Regulates Autophagy via the AMPK/mTOR Pathway to Improve SH-SY5Y-APP Cell Damage Induced by High Glucose

    Neurodegenerative diseases and postoperative cognitive dysfunction involve the accumulation of β-amyloid peptide (Aβ). High glucose can inhibit autophagy, which facilitates intracellular Aβ clearance. The α2-a...

    Pinzhong Chen, **aohui Chen, Honghong Zhang, Jianghu Chen… in NeuroMolecular Medicine (2023)

  3. Article

    Open Access

    Effect of Ultrasound-Guided Fascia Iliac Compartment Block with Nalbuphine and Ropivacaine on Preoperative Pain in Older Patients with Hip Fractures: A Multicenter, Triple-Blinded, Randomized, Controlled Trial

    Pain management for older patients with hip fractures is challenging. This study aimed to investigate the effect of ultrasound-guided fascia iliac compartment block (UGFICB) using different doses of nalbuphine...

    Fengyi Huang, Haitao Qian, Fei Gao, Jianghu Chen, Guopan Zhang… in Pain and Therapy (2022)

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