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    Article

    Dexmedetomidine Regulates Autophagy via the AMPK/mTOR Pathway to Improve SH-SY5Y-APP Cell Damage Induced by High Glucose

    Neurodegenerative diseases and postoperative cognitive dysfunction involve the accumulation of β-amyloid peptide (Aβ). High glucose can inhibit autophagy, which facilitates intracellular Aβ clearance. The α2-a...

    Pinzhong Chen, **aohui Chen, Honghong Zhang, Jianghu Chen… in NeuroMolecular Medicine (2023)

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    Article

    Amitriptyline Protects Against Lidocaine-induced Neurotoxicity in SH-SY5Y Cells via Inhibition of BDNF-mediated Autophagy

    Amitriptyline (AMI) is a traditional tricyclic antidepressant that has been proven to exhibit neuroprotective effects in various neurological disorders. However, the underlying mechanism by which AMI attenuate...

    Honghong Zhang, **aohui Chen, Ting Zheng, Mingxue Lin… in Neurotoxicity Research (2021)