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Article
Correction: Corrigendum: Detecting ultralow-frequency mutations by Duplex Sequencing
Nat. Protoc. 9, 2586–2606 (2014); doi:10.1038/nprot.2014.170; corrected online 22 October 2014 In the version of this article initially published online, the sequence for the MWS21 oligonucleotide was incorrec...
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Article
Detecting ultralow-frequency mutations by Duplex Sequencing
The high error rate of NGS methods has limited the ability to accurately detect ultra-low-frequency mutations. Duplex Sequencing reduces the error rate of NGS such that a single nucleotide mutation can be dete...
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Article
Open AccessA Rapid Assay for Measuring Nucleotide Excision Repair by Oligonucleotide Retrieval
Nucleotide excision repair (NER) excises bulky DNA lesions induced by mutagens and carcinogens. The repair process includes recognition of DNA damage, excision of a short patch of nucleotides containing the da...
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Article
Tumor suppressor p53 represses transcription of RECQ4 helicase
RECQ4 is a member of the RecQ helicase family, which has been implicated in the regulation of DNA replication, recombination and repair. p53 modulates the functions of RecQ helicases including BLM and WRN. In ...
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Article
The Werner syndrome protein is a DNA helicase
Werner syndrome (WS) is an uncommon autosomal recessive disorder characterized by premature aging. The clinical manifestations of WS, including atherosclerosis and osteoporosis, appear early in adulthood, and ...
