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Article
Open AccessDetection of miR-155-5p and imaging lung cancer for early diagnosis: in vitro and in vivo study
Currently, the routine screening program has insufficient capacity for the early diagnosis of lung cancer. Therefore, a type of chitosan-molecular beacon (CS-MB) probe was developed to recognize the miR-155-5p...
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Article
Mechanisms and pharmacokinetic/pharmacodynamic profiles underlying the low nephrotoxicity and ototoxicity of etimicin
Etimicin (ETM), a fourth-generation aminoglycosides (AGs), is now widely clinically used in China due to its high efficacy and low toxicity. However, the mechanisms underlying its low nephrotoxicity and ototox...
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Article
The lncRNA Malat1 functions as a ceRNA to contribute to berberine-mediated inhibition of HMGB1 by sponging miR-181c-5p in poststroke inflammation
Long non-coding RNAs (lncRNAs) have been identified as essential mediators in neurological dysfunction. Our previous study shows that berberine (BBR) hampers the nuclear-to-cytosolic translocation of high-mobi...
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Article
Open AccessCase report: primary resistance to osimertinib in erlotinib-pretreated lung adenocarcinoma with EGFR T790 M mutation
Among non-small cell lung cancer (NSCLC) patients with acquired T790 M mutation resistance to first-generation epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI), 71% are likely to benefit f...
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Article
Berberine attenuates ischemia–reperfusion injury through inhibiting HMGB1 release and NF-κB nuclear translocation
Inflammatory damage plays an important role in cerebral ischemic pathogenesis and represents a new target for treatment of stroke. Berberine is a natural medicine with multiple beneficial biological activities...
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Article
Isoflavones enhance pharmacokinetic exposure of active lovastatin acid via the upregulation of carboxylesterase in high-fat diet mice after oral administration of Xuezhikang capsules
Xuezhikang capsule (XZK) is a traditional Chinese medicine that contains lovastatin (Lv) for hyperlipidemia treatment, although it has fewer side effects than Lv. However, the pharmacokinetic mechanisms contri...
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Article
Joint 3D traveltime calculation based on fast marching method and wavefront construction
3D traveltime calculation is widely used in seismic exploration technologies such as seismic migration and tomography. The fast marching method (FMM) is useful for calculating 3D traveltime and has proven to b...
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Article
Development of a novel individualized warfarin dose algorithm based on a population pharmacokinetic model with improved prediction accuracy for Chinese patients after heart valve replacement
The gene-guided dosing strategy of warfarin generally leads to over-dose in patients at doses lower than 2 mg/kg, and only 50% of individual variability in daily stable doses can be explained. In this study, w...
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Article
Nonparametric estimation of interval-censored failure time data in the presence of informative censoring
Nonparametric estimation of a survival function is one of the most commonly asked questions in the analysis of failure time data and for this, a number of procedures have been developed under various types of ...
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Article
Clitocine potentiates TRAIL-mediated apoptosis in human colon cancer cells by promoting Mcl-1 degradation
Among anti-cancer candidate drugs, TRAIL might be the most specific agent against cancer cells due to its low toxicity to normal cells. Unfortunately, cancer cells usually develop drug resistance to TRAIL, whi...
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Article
Open AccessIntegrated identification, qualification and quantification strategy for pharmacokinetic profile study of Guizhi Fuling capsule in healthy volunteers
Guizhi Fuling capsule (GZFL), a traditional Chinese medicine formulation, is widely used in China to relieve pain from dysmenorrhea and is now in a Phase II clinical trial in the USA. Due to the low exposure o...
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Article
Isoflavones and phytosterols contained in Xuezhikang capsules modulate cholesterol homeostasis in high-fat diet mice
Xuezhikang (XZK), an extract of red yeast rice, has been widely used in traditional Chinese medicine to treat cardiovascular disease. Three fractions F1, F2 and F3 (primarily containing isoflavones, monacolins...
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Article
Open AccessEssential role of miR-200c in regulating self-renewal of breast cancer stem cells and their counterparts of mammary epithelium
Breast cancer stem cells (BCSCs) have been reported as the origin of breast cancer and the radical cause of drug resistance, relapse and metastasis in breast cancer. BCSCs could be derived from mutated mammary...
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Article
Clitocine targets Mcl-1 to induce drug-resistant human cancer cell apoptosis in vitro and tumor growth inhibition in vivo
Drug resistance is a major reason for therapy failure in cancer. Clitocine is a natural amino nucleoside isolated from mushroom and has been shown to inhibit cancer cell proliferation in vitro. In this study, ...
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Article
The relative role of climate change and human activities in the desertification process in Yulin region of northwest China
To overcome the shortcoming of existing studies, this paper put forward a statistical vegetation–climate relationship model with integrated temporal and spatial characteristics. Based on this model, we quantit...
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Article
Prediction of radiation pneumonitis in lung cancer patients: a systematic review
Factors prediction in the development of radiation pneumonitis (RP) remains unclear. A meta-analysis about this was performed.
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Article
The influence of sea water velocity variation on seismic traveltimes, ray paths, and amplitude
The main factors affecting seismic exploration is the propagation velocity of seismic waves in the medium. In the past, during marine seismic data processing, the propagation velocity of sea water was generall...
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Article
Aberrant microRNAs expression in CD133+/CD326+ human lung adenocarcinoma initiating cells from A549
Increasing evidence demonstrates that miRNAs are involved in the dysregulation of tumor initiating cells (TICs) in various tumors. Due to a lack of definitive markers, cell sorting is not an ideal separation m...
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Article
Open AccessMicroarray-based analysis of microRNA expression in breast cancer stem cells
This study aimed to determine the miRNA profile in breast cancer stem cells (BCSCs) and to explore the functions of characteristic BCSC miRNAs.
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Article
A New LC–MS–MS Method for Quantitative Analysis of Adefovir, and Its Use for Pharmacokinetic Studies in Healthy Chinese Volunteers
A rapid and sensitive liquid chromatographic–tandem mass spectrometric method for analysis of adefovir in human plasma has been developed and validated. After protein precipitation and evaporation, 10 μL super...
