25 Result(s)

Article

Genetic variants in FGFR2 and FGFR4 genes and skin cancer risk in the Nurses' Health Study

The human fibroblast growth factor (FGF) and its receptor (FGFR) play an important role in tumorigenesis. Deregulation of the FGFR2 gene has been identified in a number of cancer sites. Overexpression of the FGFR...

Hongmei Nan, Abrar A Qureshi, David J Hunter, Jiali Han in BMC Cancer (2009)

Article

Sphingosine-1-Phosphate Attenuates Lung Injury Induced by Intestinal Ischemia/Reperfusion in Mice: Role of Inducible Nitric-Oxide Synthase

Multiple organ failure, including acute lung injury (ALI), is a common complication of intestinal ischemia/reperfusion (I/R) injuries and contributes to its high mortality rate. Sphingosine-1-phosphate (S1P) i...

Renyu Ding, Jiali Han, Yu Tian, Renxuan Guo, **aochun Ma in Inflammation (2012)

Article

Melanocortin-1 receptor, skin cancer and phenotypic characteristics (M-SKIP) project: study design and methods for pooling results of genetic epidemiological studies

For complex diseases like cancer, pooled-analysis of individual data represents a powerful tool to investigate the joint contribution of genetic, phenotypic and environmental factors to the development of a di...

Sara Raimondi, Sara Gandini, Maria Concetta Fargnoli… in BMC Medical Research Methodology (2012)

Article

Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility

Psoriasis is a common inflammatory skin disease with complex genetics and different degrees of prevalence across ethnic populations. Here we present the largest trans-ethnic genome-wide meta-analysis (GWMA) of...

**anyong Yin, Hui Qi Low, Ling Wang, Yonghong Li, Eva Ellinghaus… in Nature Communications (2015)

Article

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716...

Yingchang Lu, Felix R. Day, Stefan Gustafsson… in Nature Communications (2016)

Article

Genome-wide association study identifies novel susceptibility loci for cutaneous squamous cell carcinoma

Cutaneous squamous cell carcinoma represents the second most common cutaneous malignancy, affecting 7–11% of Caucasians in the United States. The genetic determinants of susceptibility to cutaneous squamous ce...

Harvind S. Chahal, Yuan Lin, Katherine J. Ransohoff… in Nature Communications (2016)

Article

Genome-wide association study identifies 14 novel risk alleles associated with basal cell carcinoma

Basal cell carcinoma (BCC) is the most common cancer worldwide with an annual incidence of 2.8 million cases in the United States alone. Previous studies have demonstrated an association between 21 distinct ge...

Harvind S. Chahal, Wenting Wu, Katherine J. Ransohoff… in Nature Communications (2016)

Article

Tissue-specific Co-expression of Long Non-coding and Coding RNAs Associated with Breast Cancer

Inference of the biological roles of lncRNAs in breast cancer development remains a challenge. Here, we analyzed RNA-seq data in tumor and normal breast tissue samples from 18 breast cancer patients and 18 hea...

Wenting Wu, Erin K. Wagner, Yangyang Hao, ** Rao, Hongji Dai… in Scientific Reports (2016)

Article

Preliminary effectiveness of breast cancer screening among 1.22 million Chinese females and different cancer patterns between urban and rural women

To determine the preliminary effectiveness of breast cancer screening among Chinese females, 1226714 women aged 35–69 years first received clinical breast examinations. Urban women with suspected cancer receiv...

Yubei Huang, Hongji Dai, Fengju Song, Haixin Li, Ye Yan, Zhenhua Yang… in Scientific Reports (2016)

Article

Height, height-related SNPs, and risk of non-melanoma skin cancer

Adult height has been associated with risk of several site-specific cancers, including melanoma. However, less attention has been given to non-melanoma skin cancer (NMSC).

**n Li, Liming Liang, Yen-Chen Anne Feng, Immaculata De Vivo… in British Journal of Cancer (2017)

Article

SGLT2 inhibitors and risk of cancer in type 2 diabetes: a systematic review and meta-analysis of randomised controlled trials

The association between sodium–glucose cotransporter 2 (SGLT2) inhibitors and the risk of cancer in individuals with type 2 diabetes remains uncertain. This study aimed to evaluate the risk of cancer associate...

Huilin Tang, Qi Dai, Weilong Shi, Suodi Zhai, Yiqing Song, Jiali Han in Diabetologia (2017)

Article

Cancer risk in the EMPA-REG OUTCOME trial. Reply to Shaikh AMY [letter] and Kohler S, Lee J, George JT et al [letter]

Huilin Tang, Jiali Han, Yiqing Song in Diabetologia (2017)

Article

Diet/lifestyle and risk of diabetes and glycemic traits: a Mendelian randomization study

Observational studies have demonstrated diet/lifestyle play roles in development of type 2 diabetes (T2DM); however, it remains unclear whether these relationships are causal.

Renyu Ding, Tao Huang, Jiali Han in Lipids in Health and Disease (2018)

Article

Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure

The skin’s tendency to sunburn rather than tan is a major risk factor for skin cancer. Here we report a large genome-wide association study of ease of skin tanning in 176,678 subjects of European ancestry. We ...

Alessia Visconti, David L. Duffy, Fan Liu, Gu Zhu, Wenting Wu… in Nature Communications (2018)

Article

Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways

The total number of acquired melanocytic nevi on the skin is strongly correlated with melanoma risk. Here we report a meta-analysis of 11 nevus GWAS from Australia, Netherlands, UK, and USA comprising 52,506 i...

David L. Duffy, Gu Zhu, **n Li, Marianna Sanna, Mark M. Iles… in Nature Communications (2018)

Article

Novel disease syndromes unveiled by integrative multiscale network analysis of diseases sharing molecular effectors and comorbidities

Forty-two percent of patients experience disease comorbidity, contributing substantially to mortality rates and increased healthcare costs. Yet, the possibility of underlying shared mechanisms for diseases rem...

Haiquan Li, Jungwei Fan, Francesca Vitali, Joanne Berghout… in BMC Medical Genomics (2018)

Article

Publisher Correction: Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways

The original version of this Article contained errors in the spelling of the authors Fan Liu and M. Arfan Ikram, which were incorrectly given as Fan Lui and Arfan M. Ikram. In addition, the original version of...

David L. Duffy, Gu Zhu, **n Li, Marianna Sanna, Mark M. Iles… in Nature Communications (2019)

Article

Scalable point cloud meshing for image-based large-scale 3D modeling

Image-based 3D modeling is an effective method for reconstructing large-scale scenes, especially city-level scenarios. In the image-based modeling pipeline, obtaining a watertight mesh model from a noisy multi...

Jiali Han, Shuhan Shen in Visual Computing for Industry, Biomedicine, and Art (2019)

Article

Genome-wide meta-analysis identifies eight new susceptibility loci for cutaneous squamous cell carcinoma

Cutaneous squamous cell carcinoma (SCC) is one of the most common cancers in the United States. Previous genome-wide association studies (GWAS) have identified 14 single nucleotide polymorphisms (SNPs) associa...

Kavita Y. Sarin, Yuan Lin, Roxana Daneshjou, Andrey Ziyatdinov… in Nature Communications (2020)

Article

Speech enhancement from fused features based on deep neural network and gated recurrent unit network

Speech is easily interfered by external environment in reality, which results in the loss of important features. Deep learning has become a popular speech enhancement method because of its superior potential i...

Youming Wang, Jiali Han, Tianqi Zhang… in EURASIP Journal on Advances in Signal Proc… (2021)