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Manganese superoxide dismutase polymorphism and risk of skin cancer (United States)

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Abstract

Objective

We assessed whether the functional V16A polymorphism in the MnSOD gene is associated with skin cancer risk.

Methods

We conducted a nested case–control study (219 melanoma, 286 squamous cell carcinoma (SCC), and 300 basal cell carcinoma (BCC) cases, and 873 matched controls) within the Nurses’ Health Study. Genoty** was performed by the 5′ nuclease assay (TaqMan®). We used logistic regression to model the association between the genotype and skin cancer risk.

Results and conclusions

Overall, there was no significant association between this polymorphism and the risk of each type of skin cancer. No significant interaction was observed between this polymorphism and sunburn history and constitutional susceptibility on skin cancer risk. For interactions between intakes of α-carotene and β-carotene and the MnSOD polymorphism on SCC, the inverse association of intake of either carotene with SCC risk was limited to the Val carriers, whereas no association was observed among women with the AA genotype. We observed an interaction between total vitamin C intake and the MnSOD polymorphism on melanoma risk. No interaction was observed for the intakes of other carotenoids, vitamin E, and vitamin A. Further research is needed to confirm these possible associations.

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Abbreviations

BCC:

Basal cell carcinoma

SCC:

Squamous cell carcinoma

UV:

Ultraviolet

OR:

Odds ratio

CI:

Confidence interval

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Acknowledgments

We thank Dr. Hardeep Ranu, and Craig Labadie for their laboratory assistance, Carolyn Guo for her programming support. We are also indebted to the participants in the Nurses’ Health Study for their dedication and commitment.

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Authors and Affiliations

  1. Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, 181 Longwood Ave., Boston, MA, 02115, USA

    Jiali Han, Graham A. Colditz & David J. Hunter

  2. Department of Epidemiology, Harvard School of Public Health, 665 Huntington Ave., Boston, MA, 02115, USA

    Graham A. Colditz & David J. Hunter

  3. The Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, 665 Huntington Ave., Boston, MA, 02115, USA

    Jiali Han & David J. Hunter

Authors
  1. Jiali Han
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  2. Graham A. Colditz
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  3. David J. Hunter
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Corresponding author

Correspondence to Jiali Han.

Additional information

This work is supported by NIH grants CA113100 and CA87969. J.H. and G.A.C. are partially supported by the Harvard SPORE in Skin Cancer.

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Han, J., Colditz, G.A. & Hunter, D.J. Manganese superoxide dismutase polymorphism and risk of skin cancer (United States). Cancer Causes Control 18, 79–89 (2007). https://doi.org/10.1007/s10552-006-0079-6

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  • DOI: https://doi.org/10.1007/s10552-006-0079-6

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