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Open AccessCorrection to: binomialRF: interpretable combinatoric efficiency of random forests to identify biomarker interactions
An amendment to this paper has been published and can be accessed via the original article.
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Open AccessbinomialRF: interpretable combinatoric efficiency of random forests to identify biomarker interactions
In this era of data science-driven bioinformatics, machine learning research has focused on feature selection as users want more interpretation and post-hoc analyses for biomarker detection. However, when ther...
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Open AccessEvaluating single-subject study methods for personal transcriptomic interpretations to advance precision medicine
Gene expression profiling has benefited medicine by providing clinically relevant insights at the molecular candidate and systems levels. However, to adopt a more ‘precision’ approach that integrates individua...
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Open AccessNovel disease syndromes unveiled by integrative multiscale network analysis of diseases sharing molecular effectors and comorbidities
Forty-two percent of patients experience disease comorbidity, contributing substantially to mortality rates and increased healthcare costs. Yet, the possibility of underlying shared mechanisms for diseases rem...
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Open AccessN-of-1-pathways MixEnrich: advancing precision medicine via single-subject analysis in discovering dynamic changes of transcriptomes
Transcriptome analytic tools are commonly used across patient cohorts to develop drugs and predict clinical outcomes. However, as precision medicine pursues more accurate and individualized treatment decisions...
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USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation
Cerebral malaria infection can provoke fatal neuroinflammation. Gros and colleagues identify an ubiquitin-modification axis that exacerbates neuroinflammation and that involves TRIM25 and USP15, which jointly ...
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Erratum: USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation
Nat. Immunol.; 10.1038/ni.3581; corrected online 24 October 2016 In the version of this article initially published online, the symbol for the gene encoding granzyme B was incorrect (Gmzb) in the text in the t...
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Open AccessAnalysis of protein-coding genetic variation in 60,706 humans
Large-scale reference data sets of human genetic variation are critical for the medical and functional interpretation of DNA sequence changes. Here we describe the aggregation and analysis of high-quality exom...
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Open AccessIntegrative genomics analyses unveil downstream biological effectors of disease-specific polymorphisms buried in intergenic regions
Functionally altered biological mechanisms arising from disease-associated polymorphisms, remain difficult to characterise when those variants are intergenic, or, fall between genes. We sought to identify shar...
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Host resistance to malaria: using mouse models to explore the host response
Malaria is a disease that infects over 500 million people, causing at least 1 million deaths every year, with the majority occurring in develo** countries. The current antimalarial arsenal is becoming dulled...
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Modification of the Limulus amebocyte lysate assay for the analysis of glucan in indoor environments
β-1,3-d -Glucan is a biologically active component mainly from fungi that has been shown in several studies to be related to respiratory health outcomes from damp ...
