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  1. Article

    Open Access

    Efficacy and safety of heparin for sepsis-induced disseminated intravascular coagulation (HepSIC): study protocol for a multicenter randomized controlled trial

    Disseminated intravascular coagulation (DIC) occurs in 30–50% of septic patients and contributes to high mortality in the intensive care unit (ICU). However, there are few proven interventions for coagulation ...

    Yini Sun, Renyu Ding, Hao Sun, Yingjian Liang, **aochun Ma in Trials (2024)

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  2. Article

    Open Access

    Nanoparticles exhibiting virus-mimic surface topology for enhanced oral delivery

    The oral delivery of nano-drug delivery systems (Nano-DDS) remains a challenge. Taking inspirations from viruses, here we construct core–shell mesoporous silica nanoparticles (NPs, ~80 nm) with virus-like nano...

    Zhentao Sang, Lu Xu, Renyu Ding, Minjun Wang, **aoran Yang… in Nature Communications (2023)

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  3. Article

    Open Access

    Arnold–Chiari malformation type I and the posterior dislocation of the odontoid process aggravate prolonged weaning in a patient with severe viral pneumonia: a case report

    Prolonged and difficult weaning is associated with higher rates of complications and mortality. Therefore, it is important to identify the associated factors.

    Renyu Ding, Yulan Meng, **ngjuan Jia, **aochun Ma in BMC Pulmonary Medicine (2020)

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  4. Article

    Open Access

    Unfractionated heparin ameliorates pulmonary microvascular endothelial barrier dysfunction via microtubule stabilization in acute lung injury

    Endothelial barrier dysfunction is central to the pathogenesis of sepsis-associated acute lung injury (ALI). Microtubule (MT) dynamics in vascular endothelium are crucial for the regulation of endothelial barr...

    Shengtian Mu, Yina Liu, **g Jiang, Renyu Ding, Xu Li, **n Li… in Respiratory Research (2018)

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  5. Article

    Open Access

    Diet/lifestyle and risk of diabetes and glycemic traits: a Mendelian randomization study

    Observational studies have demonstrated diet/lifestyle play roles in development of type 2 diabetes (T2DM); however, it remains unclear whether these relationships are causal.

    Renyu Ding, Tao Huang, Jiali Han in Lipids in Health and Disease (2018)

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  6. No Access

    Article

    Heparin Rescues Sepsis-Associated Acute Lung Injury and Lethality Through the Suppression of Inflammatory Responses

    Heparin, a potent blood anticoagulant, is known to possess anti-inflammatory activity. In this work, we investigated whether heparin can ameliorate acute lung injury and lethal response in lipopolysaccharide (...

    Dongmei Zhao, Renyu Ding, Yiran Mao, Liang Wang, Zhidan Zhang, **aochun Ma in Inflammation (2012)

  7. Article

    Sphingosine-1-Phosphate Attenuates Lung Injury Induced by Intestinal Ischemia/Reperfusion in Mice: Role of Inducible Nitric-Oxide Synthase

    Multiple organ failure, including acute lung injury (ALI), is a common complication of intestinal ischemia/reperfusion (I/R) injuries and contributes to its high mortality rate. Sphingosine-1-phosphate (S1P) i...

    Renyu Ding, Jiali Han, Yu Tian, Renxuan Guo, **aochun Ma in Inflammation (2012)

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