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Article
Open AccessAssociation of sun-seeking behaviors with indoor tanning behavior in US white females during high school/college in Nurses’ Health Study II
Frequent exposure to ultraviolet light has more detrimental and longer-term effects on the skin in early life than in adulthood. Teenagers with strong sun-seeking behaviors may be more likely to use an indoor ...
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Article
Open AccessAssociation between plasma L-carnitine levels and mitochondrial DNA copy number
Mitochondria are key cytoplasmic organelles in eukaryotic cells that generate adenosine triphosphate (ATP) through the electron transport chain and oxidative phosphorylation. Mitochondrial DNA (mtDNA) copy num...
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Article
Open AccessAlcohol and Smoking Cessation as Potential Modulators for Smoking-Associated Psoriasis Risk in Postmenopausal Women: The Women’s Health Initiative
The association of alcohol with psoriasis has been inconsistent among studies.
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Article
Agent-based automated persuasion with adaptive concessions tuned by emotions
Human-to-agent automated negotiation has many potentials in a variety of applications. How to design an agent with equivalent persuasion capabilities with its human rivals is the key to the success of such sys...
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Article
Open AccessGenome-wide association meta-analysis identifies 29 new acne susceptibility loci
Acne vulgaris is a highly heritable skin disorder that primarily impacts facial skin. Severely inflamed lesions may leave permanent scars that have been associated with long-term psychosocial consequences. Her...
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Article
Open AccessSpeech enhancement from fused features based on deep neural network and gated recurrent unit network
Speech is easily interfered by external environment in reality, which results in the loss of important features. Deep learning has become a popular speech enhancement method because of its superior potential i...
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Article
Open AccessGenome-wide meta-analysis identifies eight new susceptibility loci for cutaneous squamous cell carcinoma
Cutaneous squamous cell carcinoma (SCC) is one of the most common cancers in the United States. Previous genome-wide association studies (GWAS) have identified 14 single nucleotide polymorphisms (SNPs) associa...
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Article
Open AccessScalable point cloud meshing for image-based large-scale 3D modeling
Image-based 3D modeling is an effective method for reconstructing large-scale scenes, especially city-level scenarios. In the image-based modeling pipeline, obtaining a watertight mesh model from a noisy multi...
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Open AccessPublisher Correction: Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways
The original version of this Article contained errors in the spelling of the authors Fan Liu and M. Arfan Ikram, which were incorrectly given as Fan Lui and Arfan M. Ikram. In addition, the original version of...
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Open AccessNovel disease syndromes unveiled by integrative multiscale network analysis of diseases sharing molecular effectors and comorbidities
Forty-two percent of patients experience disease comorbidity, contributing substantially to mortality rates and increased healthcare costs. Yet, the possibility of underlying shared mechanisms for diseases rem...
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Article
Open AccessNovel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways
The total number of acquired melanocytic nevi on the skin is strongly correlated with melanoma risk. Here we report a meta-analysis of 11 nevus GWAS from Australia, Netherlands, UK, and USA comprising 52,506 i...
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Article
Open AccessGenome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure
The skin’s tendency to sunburn rather than tan is a major risk factor for skin cancer. Here we report a large genome-wide association study of ease of skin tanning in 176,678 subjects of European ancestry. We ...
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Open AccessDiet/lifestyle and risk of diabetes and glycemic traits: a Mendelian randomization study
Observational studies have demonstrated diet/lifestyle play roles in development of type 2 diabetes (T2DM); however, it remains unclear whether these relationships are causal.
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Article
Cancer risk in the EMPA-REG OUTCOME trial. Reply to Shaikh AMY [letter] and Kohler S, Lee J, George JT et al [letter]
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Article
SGLT2 inhibitors and risk of cancer in type 2 diabetes: a systematic review and meta-analysis of randomised controlled trials
The association between sodium–glucose cotransporter 2 (SGLT2) inhibitors and the risk of cancer in individuals with type 2 diabetes remains uncertain. This study aimed to evaluate the risk of cancer associate...
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Article
Open AccessHeight, height-related SNPs, and risk of non-melanoma skin cancer
Adult height has been associated with risk of several site-specific cancers, including melanoma. However, less attention has been given to non-melanoma skin cancer (NMSC).
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Article
Open AccessPreliminary effectiveness of breast cancer screening among 1.22 million Chinese females and different cancer patterns between urban and rural women
To determine the preliminary effectiveness of breast cancer screening among Chinese females, 1226714 women aged 35–69 years first received clinical breast examinations. Urban women with suspected cancer receiv...
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Article
Open AccessTissue-specific Co-expression of Long Non-coding and Coding RNAs Associated with Breast Cancer
Inference of the biological roles of lncRNAs in breast cancer development remains a challenge. Here, we analyzed RNA-seq data in tumor and normal breast tissue samples from 18 breast cancer patients and 18 hea...
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Article
Open AccessGenome-wide association study identifies 14 novel risk alleles associated with basal cell carcinoma
Basal cell carcinoma (BCC) is the most common cancer worldwide with an annual incidence of 2.8 million cases in the United States alone. Previous studies have demonstrated an association between 21 distinct ge...
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Article
Open AccessGenome-wide association study identifies novel susceptibility loci for cutaneous squamous cell carcinoma
Cutaneous squamous cell carcinoma represents the second most common cutaneous malignancy, affecting 7–11% of Caucasians in the United States. The genetic determinants of susceptibility to cutaneous squamous ce...
