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  1. No Access

    Article

    Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility

    Most genetic susceptibility to cutaneous melanoma remains to be discovered. Meta-analysis genome-wide association study (GWAS) of 36,760 cases of melanoma (67% newly genotyped) and 375,188 controls identified ...

    Maria Teresa Landi, D. Timothy Bishop, Stuart MacGregor… in Nature Genetics (2020)

  2. Article

    Open Access

    Novel disease syndromes unveiled by integrative multiscale network analysis of diseases sharing molecular effectors and comorbidities

    Forty-two percent of patients experience disease comorbidity, contributing substantially to mortality rates and increased healthcare costs. Yet, the possibility of underlying shared mechanisms for diseases rem...

    Haiquan Li, Jungwei Fan, Francesca Vitali, Joanne Berghout… in BMC Medical Genomics (2018)

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  3. Article

    Open Access

    Height, height-related SNPs, and risk of non-melanoma skin cancer

    Adult height has been associated with risk of several site-specific cancers, including melanoma. However, less attention has been given to non-melanoma skin cancer (NMSC).

    **n Li, Liming Liang, Yen-Chen Anne Feng, Immaculata De Vivo… in British Journal of Cancer (2017)

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  4. No Access

    Article

    Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma

    Matthew Law, Mark Iles and colleagues report the results of a large-scale genome-wide meta-analysis of cutaneous malignant melanoma. They confirm previously reported association signals and identify five new s...

    Matthew H Law, D Timothy Bishop, Jeffrey E Lee, Myriam Brossard… in Nature Genetics (2015)

  5. No Access

    Article

    Association between BRAF V600E and NRAS Q61R mutations and clinicopathologic characteristics, risk factors and clinical outcome of primary invasive cutaneous melanoma

    Previous studies suggest that solar UV exposure in early life is predictive of cutaneous melanoma risk in adulthood, whereas the relation of BRAF mutation with sun exposure and disease prognosis has been less ...

    Shaowei Wu, Helen Kuo, Wen-Qing Li, Alvaro Laga Canales… in Cancer Causes & Control (2014)

  6. No Access

    Article

    A genome-wide association study of severe teenage acne in European Americans

    Despite the family aggregation of severe teenage acne, the genetic basis of this common skin condition remains unclear. We conducted a genome-wide association study (GWAS) on severe teenage acne in 928 Europea...

    Mingfeng Zhang, Abrar A. Qureshi, David J. Hunter, Jiali Han in Human Genetics (2014)

  7. No Access

    Article

    CXCR4 pathway associated with family history of melanoma

    Genetic predisposition plays a major role in the etiology of melanoma, but known genetic markers only account for a limited fraction of family-history-associated melanoma cases. Expression microarrays have of...

    Wen-Qing Li, Jiali Han, Hans R. Widlund, Mick Correll… in Cancer Causes & Control (2014)

  8. No Access

    Article

    Obesity-related genetic variants, human pigmentation, and risk of melanoma

    Previous biological studies showed evidence of a genetic link between obesity and pigmentation in both animal models and humans. Our study investigated the individual and joint associations between obesity-rel...

    **n Li, Liming Liang, Mingfeng Zhang, Fengju Song, Hongmei Nan, Li-E Wang… in Human Genetics (2013)

  9. No Access

    Article

    Obesity and the incidence of skin cancer in US Caucasians

    Limited information is available on the potential link between obesity and either melanoma or non-melanoma skin cancers.

    Salma Pothiawala, Abrar A. Qureshi, Yunhui Li, Jiali Han in Cancer Causes & Control (2012)

  10. No Access

    Article

    Integrating pathway analysis and genetics of gene expression for genome-wide association study of basal cell carcinoma

    Genome-wide association studies (GWASs) have primarily focused on marginal effects for individual markers and have incorporated external functional information only after identifying robust statistical associa...

    Mingfeng Zhang, Liming Liang, Nilesh Morar, Anna L. Dixon… in Human Genetics (2012)

  11. Article

    Sphingosine-1-Phosphate Attenuates Lung Injury Induced by Intestinal Ischemia/Reperfusion in Mice: Role of Inducible Nitric-Oxide Synthase

    Multiple organ failure, including acute lung injury (ALI), is a common complication of intestinal ischemia/reperfusion (I/R) injuries and contributes to its high mortality rate. Sphingosine-1-phosphate (S1P) i...

    Renyu Ding, Jiali Han, Yu Tian, Renxuan Guo, **aochun Ma in Inflammation (2012)

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  12. No Access

    Article

    Genome-wide association study identifies three new melanoma susceptibility loci

    Timothy Bishop and colleagues of the GenoMEL Consortium report a genome-wide association study for melanoma, identifying three new susceptibility loci.

    Jennifer H Barrett, Mark M Iles, Mark Harland, John C Taylor… in Nature Genetics (2011)

  13. No Access

    Article

    Genome-wide association study identifies a new melanoma susceptibility locus at 1q21.3

    Stuart MacGregor and colleagues report the results of a genome-wide association study for melanoma susceptibility in an Australian population. They identify a new melanoma susceptibility locus on chromosome 1.

    Stuart MacGregor, Grant W Montgomery, Jimmy Z Liu, Zhen Zhen Zhao… in Nature Genetics (2011)

  14. No Access

    Article

    ASIP genetic variants and the number of non-melanoma skin cancers

    Patients with primary non-melanoma skin cancers (NMSCs) tend to develop these cancers at multiple independent sites. We examined the genetic factors in the development of multiple NMSCs among Caucasian women w...

    Wen Lin, Abrar A. Qureshi, Peter Kraft, Hongmei Nan, Qun Guo… in Cancer Causes & Control (2011)

  15. No Access

    Article

    Genetic variants in telomere-maintaining genes and skin cancer risk

    Telomere-related genes play an important role in maintaining the integrity of the telomeric structure that protects chromosome ends, and telomere dysfunction may lead to tumorigenesis. We evaluated the associa...

    Hongmei Nan, Abrar A. Qureshi, Jennifer Prescott, Immaculata De Vivo… in Human Genetics (2011)

  16. Article

    Open Access

    Genetic variants in FGFR2 and FGFR4 genes and skin cancer risk in the Nurses' Health Study

    The human fibroblast growth factor (FGF) and its receptor (FGFR) play an important role in tumorigenesis. Deregulation of the FGFR2 gene has been identified in a number of cancer sites. Overexpression of the FGFR...

    Hongmei Nan, Abrar A Qureshi, David J Hunter, Jiali Han in BMC Cancer (2009)

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  17. No Access

    Article

    A functional SNP in the MDM2 promoter, pigmentary phenotypes, and risk of skin cancer

    The MDM2 oncoprotein is a key negative regulator of the tumor suppressor p53. A functional MDM2 single nucleotide polymorphism (SNP309) in the promoter region increases the affinity of transcription activator ...

    Hongmei Nan, Abrar A. Qureshi, David J. Hunter, Jiali Han in Cancer Causes & Control (2009)

  18. No Access

    Article

    Manganese superoxide dismutase polymorphism and risk of skin cancer (United States)

    We assessed whether the functional V16A polymorphism in the MnSOD gene is associated with skin cancer risk.

    Jiali Han, Graham A. Colditz, David J. Hunter in Cancer Causes & Control (2007)