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  1. Article

    Open Access

    Multi-site tumor sampling highlights molecular intra-tumor heterogeneity in malignant pleural mesothelioma

    Malignant pleural mesothelioma (MPM) is a heterogeneous cancer. Better knowledge of molecular and cellular intra-tumor heterogeneity throughout the thoracic cavity is required to develop efficient therapies. T...

    Clément Meiller, François Montagne, Theo Z. Hirsch, Stefano Caruso… in Genome Medicine (2021)

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    Article

    Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas

    Jessica Zucman-Rossi and colleagues identify clonal integrations of adeno-associated virus type 2 (AAV2) in hepatocellular carcinomas. These AAV2 integrations occurred within known cancer driver genes, suggest...

    Jean-Charles Nault, Shalini Datta, Sandrine Imbeaud, Andrea Franconi… in Nature Genetics (2015)

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    Article

    Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets

    Jessica Zucman-Rossi and colleagues report exome sequences of 243 hepatocellular carcinomas. They identify mutational signatures associated with specific risk factors such as alcohol, tobacco and aflatoxin B1 ...

    Kornelius Schulze, Sandrine Imbeaud, Eric Letouzé, Ludmil B Alexandrov… in Nature Genetics (2015)

  4. No Access

    Article

    Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma

    Jessica Zucman-Rossi and colleagues report exome sequencing of 24 hepatocellular carcinomas and non-tumor liver tissues and copy-number analysis of 125 tumors. They identify new recurrent mutations in ARID1A, RPS...

    Cécile Guichard, Giuliana Amaddeo, Sandrine Imbeaud, Yannick Ladeiro… in Nature Genetics (2012)

  5. No Access

    Article

    Loss of Trim24 (Tif1α) gene function confers oncogenic activity to retinoic acid receptor alpha

    Hepatocellular carcinoma (HCC) is a major cause of death worldwide. Here, we provide evidence that the ligand-dependent nuclear receptor co-regulator Trim24 (also known as Tif1α) functions in mice as a liver-s...

    Konstantin Khetchoumian, Marius Teletin, Johan Tisserand, Manuel Mark… in Nature Genetics (2007)

  6. No Access

    Article

    Bi-allelic inactivation of TCF1 in hepatic adenomas

    Liver adenomas are benign tumors at risk of malignant transformation. In a genome-wide search for loss of heterozygosity (LOH) associated with liver adenomas, we found a deletion in chromosome 12q in five of t...

    Olivier Bluteau, Emmanuelle Jeannot, Paulette Bioulac-Sage… in Nature Genetics (2002)

  7. No Access

    Article

    Interethnic polymorphism of EWS intron 6: genome plasticity mediated by Alu retroposition and recombination

    The EWS gene has been identified as being systematically translocated in Ewing’s sarcoma. In order to ascertain the basis of a marked interethnic difference in the incidence of Ewing’s sarcoma, intron 6 of EW...

    Jessica Zucman-Rossi, Mark A. Batzer, Mark Stoneking, Olivier Delattre… in Human Genetics (1997)