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Article
Incidence and clinical impact of bile ducts changes after multibipolar radiofrequency ablation for hepatocellular carcinoma
This study aimed to evaluate the incidence and clinical implications of bile duct changes following multibipolar radiofrequency ablation (mbpRFA) for hepatocellular carcinoma (HCC).
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Article
Open AccessImaging and histological features of tumor biopsy sample predict aggressive intrasegmental recurrence of hepatocellular carcinoma after radiofrequency ablation
Aggressive intrasegmental recurrence (AIR) is a form of local recurrence associated with a dismal prognosis and defined by multiple nodules or by an infiltrative mass with a tumor thrombus, occurring in the tr...
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Article
Benign liver tumours: understanding molecular physiology to adapt clinical management
Improvements in understanding the pathophysiology of the different benign liver nodules have refined their nosological classification. New criteria have been identified using imaging, histology and molecular a...
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Article
Evaluation of perfusion CT and dual-energy CT for predicting microvascular invasion of hepatocellular carcinoma
Evaluation of perfusion CT and dual-energy CT (DECT) quantitative parameters for predicting microvascular invasion (MVI) of hepatocellular carcinoma (HCC) prior to surgery.
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Article
The role of telomeres and telomerase in cirrhosis and liver cancer
Telomerase is a key enzyme for cell survival that prevents telomere shortening and the subsequent cellular senescence that is observed after many rounds of cell division. In contrast, inactivation of telomeras...
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Article
Open AccessCyclin A2/E1 activation defines a hepatocellular carcinoma subclass with a rearrangement signature of replication stress
Cyclins A2 and E1 regulate the cell cycle by promoting S phase entry and progression. Here, we identify a hepatocellular carcinoma (HCC) subgroup exhibiting cyclin activation through various mechanisms includi...
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Article
Open AccessThe clinical implications of G1-G6 transcriptomic signature and 5-gene score in Korean patients with hepatocellular carcinoma
Efforts have been made to classify Hepatocellular Carcinoma (HCC) at surgically curable stages because molecular classification, which is prognostically informative, can accurately identify patients in need of...
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Article
Hepatocellular Carcinoma: the Impact of NAFLD
The burden of chronic liver diseases including hepatocellular carcinoma (HCC) due to non-alcoholic steatohepatitis (NASH) and metabolic syndrome (MS) is increasing worldwide. Moreover, MS and its components ac...
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Article
A MYC–aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer
In Trp53-mutated hepatocellular carcinoma, conformation-changing aurora kinase A inhibitors disrupt aurora kinase A–MYC interactions, resulting in MYC degradation and suppression of tumor growth.
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Article
Percutaneous Treatment of Localized Infiltrative Hepatocellular Carcinoma Develo** on Cirrhosis
Infiltrating hepatocellular carcinoma (HCC) is characterized by a difficult diagnosis, dismal prognosis, and limited therapeutic options. We describe long-term results of percutaneous treatment of infiltrativ...
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Chapter
Genomic Signatures of Risk Factors and Molecular Identification of HCC Subtypes
The main risk factors of HCC (infections by hepatitis B or C viruses, high alcohol consumption, metabolic genetic diseases or obesity) predispose to chronic liver disease leading to cirrhosis development, a ma...
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Article
Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas
Jessica Zucman-Rossi and colleagues identify clonal integrations of adeno-associated virus type 2 (AAV2) in hepatocellular carcinomas. These AAV2 integrations occurred within known cancer driver genes, suggest...
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Article
Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets
Jessica Zucman-Rossi and colleagues report exome sequences of 243 hepatocellular carcinomas. They identify mutational signatures associated with specific risk factors such as alcohol, tobacco and aflatoxin B1 ...
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Article
Open AccessOverexpression of phosphatidylinositol 4-kinase type IIIα is associated with undifferentiated status and poor prognosis of human hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a particularly severe disease characterized by a high rate of recurrence and death even after surgical resection. Molecular characterization of HCC helps refine prognosis and ...
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Article
ALDH3A1 is overexpressed in a subset of hepatocellular carcinoma characterised by activation of the Wnt/ß-catenin pathway
Aldehyde dehydrogenase isoforms, ALDH1A1 and ALDH3A1, are associated with poor clinical outcome and resistance to chemotherapy in a wide variety of human malignancies. So far, their expression and prognostic s...
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Article
Correction: Corrigendum: High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions
Nature Communications 4: Article number: 2218 (2013); Published: 26 July 2013; Updated: 10 October 2013. The original version of this Article contained a typographical error in the spelling of the author Jessi...
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Article
Open AccessHigh frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions
Somatic mutations activating telomerase reverse-trancriptase promoter were recently identified in several tumour types. Here we identify frequent similar mutations in human hepatocellular carcinomas (59%), cir...
