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Article
Open AccessExtensive nuclear reprogramming and endoreduplication in mature leaf during floral induction
The floral transition is a complex developmental event, fine-tuned by various environmental and endogenous cues to ensure the success of offspring production. Leaves are key organs in sensing floral inductive ...
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Article
Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma
Jessica Zucman-Rossi and colleagues report exome sequencing of 24 hepatocellular carcinomas and non-tumor liver tissues and copy-number analysis of 125 tumors. They identify new recurrent mutations in ARID1A, RPS...
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Article
Open AccessExploration of plant genomes in the FLAGdb++ environment
In the contexts of genomics, post-genomics and systems biology approaches, data integration presents a major concern. Databases provide crucial solutions: they store, organize and allow information to be queri...
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Article
Open AccessPatterns of sequence polymorphism in the fleshless berry locus in cultivated and wild Vitis vinifera accessions
Unlike in tomato, little is known about the genetic and molecular control of fleshy fruit development of perennial fruit trees like grapevine (Vitis vinifera L.). Here we present the study of the sequence polymor...
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Article
Identification, genomic organization, chromosomal map** and mutation analysis of the human INV gene, the ortholog of a murine gene implicated in left-right axis development and biliary atresia
Determination of left-right axis is a precocious embryonic event, and all phenotypic anomalies resulting from disruption of the normal lateralization process are collectively referred to as the lateralization...
