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Article
Mutations in the cardiac troponin I gene associated with hypertrophic cardiomyopathy
Hypertrophic cardiomyopathy (HCM), the most common cause of sudden death in the young, is an autosomal dominant disease characterized by ventricular hypertrophy accompanied by myofibrillar disarrays1. Linkage stu...
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Article
Open AccessActivation of monocytes, T-lymphocytes and plasma inflammatory markers in angina patients
Inflammation and activation of immune cells have important roles in the pathogenesis of atherosclerosis. We analyzed the plasma levels of inflammatory markers and the degree of activation of peripheral blood m...
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Chapter
Mutational Profiles and Molecular Etiologies of Hypertrophic Cardiomyopathy and Dilated Cardiomyopathy in Asian Populations
Idiopathic cardiomyopathy (ICM) had been defined as the cardiac disease of unknown etiology. There are two major clinical phenotypes of ICM; hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM). ...
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Article
Open AccessInvolvement of tumor necrosis factor receptor superfamily (TNFRSF) members in the pathogenesis of inflammatory diseases
Current therapies for autoimmune diseases are not cures but merely palliatives, aimed at reducing symptoms. For the most part, these treatments provide nonspecific suppression of the immune system and thus do ...
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Article
Replication of the association between a chromosome 9p21 polymorphism and coronary artery disease in Japanese and Korean populations
Coronary artery disease (CAD) has become a major health problem in many countries. Recent genome-wide association studies have identified the association between rs1333049 on chromosome 9p21 and susceptibility...
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Article
Megakaryoblastic leukemia factor-1 gene in the susceptibility to coronary artery disease
Coronary artery disease (CAD) is based on the atherosclerosis of coronary artery and may manifest with myocardial infarction or angina pectoris. Although it is widely accepted that genetic factors are linked t...
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Article
Open AccessEfficacy, safety, and tolerability of valsartan/hydrochlorothiazide in Asian patients with essential hypertension
Previous studies have demonstrated that hypertensive patients need concomitant therapy with one or more drugs from different classes of antihypertensive agents to achieve their blood pressure control targets. ...
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Article
Complete versus incomplete revascularization for treatment of multivessel coronary artery disease in the drug-eluting stent era
Limited data exist regarding the impact of complete revascularization (CR) versus incomplete revascularization (IR) on the long-term outcomes of patients with multivessel coronary artery disease (MVD) who unde...
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Article
Lipoteichoic acid isolated from Lactobacillus plantarum suppresses LPS-mediated atherosclerotic plaque inflammation
Chronic inflammation plays an important role in atherogenesis. Experimental studies have demonstrated the accumulation of monocytes/macrophages in atherosclerotic plaques caused by inflammation. Here, we repor...
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Article
Genome-based exome sequencing analysis identifies GYG1, DIS3L and DDRGK1 are associated with myocardial infarction in Koreans
Myocardial infarction (MI) is a complex disease caused by combination of genetic and environmental factors. Although genome-wide association studies (GWAS) identified more than 46 risk loci which are associate...
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Article
Open AccessMechanistic insights into the anti-restenotic effects of HSP27 and HO1 modulated by reconstituted HDL on neointimal hyperplasia
High-density lipoprotein (HDL) therapy has demonstrated beneficial effects in acute stroke and acute myocardial infarction models by reducing infarct size. In this study, we investigated the inhibitory effects...
