-
Article
Open AccessPopulation genetic considerations regarding the interpretation of within-patient SARS-CoV-2 polymorphism data
-
Article
Population genetic concerns related to the interpretation of empirical outliers and the neglect of common evolutionary processes
-
Article
Inferring the distribution of fitness effects in patient-sampled and experimental virus populations: two case studies
We here propose an analysis pipeline for inferring the distribution of fitness effects (DFE) from either patient-sampled or experimentally-evolved viral populations, that explicitly accounts for non-Wright-Fis...
-
Article
The population genomics of within-host Mycobacterium tuberculosis
Recent progress in genomic sequencing from patient samples has allowed for the first detailed insight into the within-host genetic diversity of Mycobacterium tuberculosis (M.TB), revealing remarkably low levels o...
-
Article
Considering mutational meltdown as a potential SARS-CoV-2 treatment strategy
-
Article
Open AccessThe population genetics of crypsis in vertebrates: recent insights from mice, hares, and lizards
By combining well-established population genetic theory with high-throughput sequencing data from natural populations, major strides have recently been made in understanding how, why, and when vertebrate popul...
-
Article
The fitness landscape of the codon space across environments
Fitness landscapes map the relationship between genotypes and fitness. However, most fitness landscape studies ignore the genetic architecture imposed by the codon table and thereby neglect the potential role ...
-
Article
On the unfounded enthusiasm for soft selective sweeps
Patterns of genomic variation can be used to identify targets of positive selection but understanding their mode of evolution is challenging. This review discusses theory and empirical evidence regarding soft ...
-
Article
Resequencing 50 accessions of cultivated and wild rice yields markers for identifying agronomically important genes
A catalog of genetic variation in a crop species facilitates marker-assisted breeding, gene map** and analysis of elite traits. Xu et al. resequenced 40 cultivated and 10 wild rice accessions to >15 × coverage,...
-
Article
Open AccessSimilar Levels of X-linked and Autosomal Nucleotide Variation in African and non-African populations of Drosophila melanogaster
Levels of molecular diversity in Drosophila have repeatedly been shown to be higher in ancestral, African populations than in derived, non-African populations. This pattern holds for both coding and noncoding ...
