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Article
Gene expression across mammalian organ development
The evolution of gene expression in mammalian organ development remains largely uncharacterized. Here we report the transcriptomes of seven organs (cerebrum, cerebellum, heart, kidney, liver, ovary and testis)...
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Article
Open AccessRepurposing of promoters and enhancers during mammalian evolution
Promoters and enhancers—key controllers of gene expression—have long been distinguished from each other based on their function. However, recent work suggested that common architectural and functional features...
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Article
Open AccessConserved microRNA editing in mammalian evolution, development and disease
Mammalian microRNAs (miRNAs) are sometimes subject to adenosine-to-inosine RNA editing, which can lead to dramatic changes in miRNA target specificity or expression levels. However, although a few miRNAs are k...
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Article
Open AccessGlobal kinomic and phospho-proteomic analyses of the human malaria parasite Plasmodium falciparum
The role of protein phosphorylation in the life cycle of malaria parasites is slowly emerging. Here we combine global phospho-proteomic analysis with kinome-wide reverse genetics to assess the importance of pr...
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Article
Open AccessHost genotype by parasite genotype interactions underlying the resistance of anopheline mosquitoes to Plasmodium falciparum
Most studies on the resistance of mosquitoes to their malaria parasites focus on the response of a mosquito line or colony against a single parasite genotype. In natural situations, however, it may be expected...
