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Article
Transcriptome and translatome co-evolution in mammals
Gene-expression programs define shared and species-specific phenotypes, but their evolution remains largely uncharacterized beyond the transcriptome layer1. Here we report an analysis of the co-evolution of trans...
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Article
Gene expression across mammalian organ development
The evolution of gene expression in mammalian organ development remains largely uncharacterized. Here we report the transcriptomes of seven organs (cerebrum, cerebellum, heart, kidney, liver, ovary and testis)...
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Article
Open AccessRepurposing of promoters and enhancers during mammalian evolution
Promoters and enhancers—key controllers of gene expression—have long been distinguished from each other based on their function. However, recent work suggested that common architectural and functional features...
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Article
Open AccessConserved microRNA editing in mammalian evolution, development and disease
Mammalian microRNAs (miRNAs) are sometimes subject to adenosine-to-inosine RNA editing, which can lead to dramatic changes in miRNA target specificity or expression levels. However, although a few miRNAs are k...
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Article
Origins and functional evolution of Y chromosomes across mammals
Y chromosomes underlie sex determination in mammals, but their repeat-rich nature has hampered sequencing and associated evolutionary studies. Here we trace Y evolution across 15 representative mammals on the ...
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Article
The evolution of lncRNA repertoires and expression patterns in tetrapods
Only a very small fraction of long noncoding RNAs (lncRNAs) are well characterized. The evolutionary history of lncRNAs can provide insights into their functionality, but the absence of lncRNA annotations in n...
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Article
The evolution of gene expression levels in mammalian organs
Changes in gene expression are thought to underlie many of the phenotypic differences between species. However, large-scale analyses of gene expression evolution were until recently prevented by technological ...
