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  1. No Access

    Article

    Depleting myeloid-biased haematopoietic stem cells rejuvenates aged immunity

    Ageing of the immune system is characterized by decreased lymphopoiesis and adaptive immunity, and increased inflammation and myeloid pathologies1,2. Age-related changes in populations of self-renewing haematopoi...

    Jason B. Ross, Lara M. Myers, Joseph J. Noh, Madison M. Collins, Aaron B. Carmody… in Nature (2024)

  2. Article

    Open Access

    Radiotherapy in combination with CD47 blockade elicits a macrophage-mediated abscopal effect

    Radiation therapy is a mainstay of cancer treatment but does not always lead to complete tumor regression. Here we combine radiotherapy with blockade of the ‘don’t-eat-me’ cell-surface molecule CD47 in small c...

    Yoko Nishiga, Alexandros P. Drainas, Maya Baron, Debadrita Bhattacharya… in Nature Cancer (2022)

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    Article

    Identification of molecular determinants of primary and metastatic tumour re-initiation in breast cancer

    Through in vivo selection of multiple ER-negative human breast cancer populations for enhanced tumour-forming capacity, we have derived subpopulations that generate tumours more efficiently than their parental po...

    Jason B. Ross, Doowon Huh, Lisa B. Noble, Sohail F. Tavazoie in Nature Cell Biology (2015)